Michael R P, Rees H D
Life Sci. 1982 Jun 14;30(24):2087-93. doi: 10.1016/0024-3205(82)90450-7.
In a preliminary study, autoradiography was used to localize target cells for 3H-dihydrotestosterone (DHT), a non-aromatizable androgen, in the brain of the rhesus monkey. One castrated male was injected intravenously with 2 mCi of 3H-DHT (0.42 microgram/kg), and was killed one hour later. Neurons that concentrated radioactivity in their nuclei were located in widespread areas of the brain, which included the medial and suprachiasmatic preoptic nuclei, bed nucleus of the stria terminalis, lateral septal nucleus, anterior hypothalamic area, ventromedial, arcuate, dorsomedial, and paraventricular hypothalamic nuclei, ventral premammillary nucleus, and medial, cortical, basal accessory, and lateral amygdaloid nuclei. These results indicate that the topographic distribution of androgen target neurons is considerably wider than that observed in a study using 3H-testosterone (T) in the male rhesus monkey (1). However, further work is needed to elucidate these differences before attempting correlations between behavioral activity and androgen receptors in the brain.
在一项初步研究中，利用放射自显影术在恒河猴大脑中定位了非芳香化雄激素3H-双氢睾酮（DHT）的靶细胞。给一只去势雄性恒河猴静脉注射2毫居里的3H-DHT（0.42微克/千克），1小时后将其处死。细胞核中集中放射性的神经元位于大脑的广泛区域，包括内侧和视交叉上视前核、终纹床核、外侧隔核、下丘脑前区、腹内侧、弓状、背内侧和室旁下丘脑核、腹侧乳头前核以及内侧、皮质、基底副和外侧杏仁核。这些结果表明，雄激素靶神经元的拓扑分布比在雄性恒河猴中使用3H-睾酮（T）的研究中观察到的要广泛得多（1）。然而，在尝试将行为活动与大脑中的雄激素受体进行关联之前，需要进一步开展工作以阐明这些差异。
