Dover G
Nature. 1982 Sep 9;299(5879):111-7. doi: 10.1038/299111a0.
It is generally accepted that mutations may become fixed in a population by natural selection and genetic drift. In the case of many families of genes and noncoding sequences, however, fixation of mutations within a population may proceed as a consequence of molecular mechanisms of turnover within the genome. These mechanisms can be both random and directional in activity. There are circumstances in which the unusual concerted pattern of fixation permits the establishment of biological novelty and species discontinuities in a manner not predicted by the classical genetics of natural selection and genetic drift.
一般认为，突变可通过自然选择和遗传漂变在种群中固定下来。然而，对于许多基因家族和非编码序列而言，种群内突变的固定可能是基因组内更替分子机制的结果。这些机制在活性上既可以是随机的，也可以是定向的。在某些情况下，这种不寻常的协同固定模式能够以一种经典的自然选择和遗传漂变遗传学未预测到的方式建立生物新奇性和物种间断性。
