Netti C, Guidobono F, Olgiati V R, Sibilia V, Pagani F, Pecile A
Neuroendocrinology. 1982;35(1):43-7. doi: 10.1159/000123353.
The effects of histamine and amodiaquine (a drug known to inhibit histamine-N-methyltransferase) on pulsatile growth hormone (GH) secretion were determined in unanaesthetized male rats. Intracerebroventricular (i.c.v.) administration of histamine (0.01, 0.05, 0.1 mumol/rat) caused a dose-related suppression of spontaneous pulses of rat GH (rGH) secretion. Amodiaquine (0.16 mumol/rat i.c.v.) also inhibited the pulses, but to a lesser degree. The results, which show the inhibitory effects of both exogenous histamine and increased levels of endogenous histamine on pulsatile rGH secretion, support the hypothesis that the histaminergic system also plays a role in physiological CNS control of rGH secretion.
在未麻醉的雄性大鼠中测定了组胺和阿莫地喹（一种已知可抑制组胺 - N - 甲基转移酶的药物）对脉冲式生长激素（GH）分泌的影响。脑室内（i.c.v.）注射组胺（0.01、0.05、0.1 μmol/大鼠）导致大鼠GH（rGH）分泌的自发性脉冲出现剂量相关的抑制。阿莫地喹（0.16 μmol/大鼠i.c.v.）也抑制了这些脉冲，但程度较轻。这些结果表明外源性组胺和内源性组胺水平升高均对脉冲式rGH分泌有抑制作用，支持了组胺能系统在rGH分泌的生理性中枢神经系统控制中也起作用这一假说。
