Erenberg A, Frank L, Roberts R J, Rhodes M L
Pediatr Res. 1982 Jul;16(7):570-2. doi: 10.1203/00006450-198207000-00017.
Pulmonary superoxide dismutase (SOD) activity was measured in 11 euthyroid and 15 hypothyroid ovine fetuses at 130 days gestation. In the euthyroid fetus, the mean pulmonary SOD activity was similar in saline- and thyroxine-infused groups. Compared to the euthyroid fetus, the mean pulmonary SOD activity was significantly lower in the noninfused or saline-infused athyrotic fetus. Administration of thyroxine to the hypothyroid fetus results in a normalization of pulmonary SOD activity to control values. Thus, thyroxine appears to influence the maturation of pulmonary SOD activity in the ovine fetus during the third trimester.
在妊娠130天时，对11只甲状腺功能正常和15只甲状腺功能减退的绵羊胎儿进行了肺超氧化物歧化酶（SOD）活性测定。在甲状腺功能正常的胎儿中，生理盐水注入组和甲状腺素注入组的平均肺SOD活性相似。与甲状腺功能正常的胎儿相比，未注入或注入生理盐水的无甲状腺胎儿的平均肺SOD活性显著降低。对甲状腺功能减退的胎儿给予甲状腺素可使肺SOD活性恢复至对照值的正常水平。因此，甲状腺素似乎在妊娠晚期影响绵羊胎儿肺SOD活性的成熟。
