Morselli P L, Bianchetti G, Durand G, Le Heuzey M F, Zarifian E, Dugas M
Ther Drug Monit. 1979;1(1):35-46. doi: 10.1097/00007691-197901000-00004.
Plasma levels of haloperidol were monitored in children and teenagers suffering from psychotic episodes and/or abnormal movements (tics and Gilles de la Tourette's syndrome). Steady-state concentrations of haloperidol ranged from 0.7 to 19 ng/ml without any apparent relationship with the administered dose (15--285 micrograms/kg/day) and a 15-fold variability was observed for the same daily dosage. On the contrary, a significant (p < 0.02) relationship was found between the age of the patients and the plasma concentrations to dose ratios, lower values being present in younger patients. Side effects too appeared to be related to plasma levels, with a significant increase (p < 0.01) in incidence for concentrations over 6 ng/ml. In most of the cases suffering from tics and Gilles de la Tourette's syndrome, a positive response was associated with plasma levels of 1--4 ng/ml, while no relationship could be established for the psychotic group. The relevance of monitoring plasma drug levels when prescribing haloperidol in pediatrics is discussed.
对患有精神病发作和/或异常运动（抽动和图雷特综合征）的儿童和青少年进行了氟哌啶醇血药浓度监测。氟哌啶醇的稳态浓度范围为0.7至19纳克/毫升，与给药剂量（15 - 285微克/千克/天）无明显关系，且相同日剂量下观察到15倍的变异性。相反，患者年龄与血药浓度与剂量比值之间存在显著（p < 0.02）关系，年轻患者的值较低。副作用似乎也与血药浓度有关，浓度超过6纳克/毫升时发生率显著增加（p < 0.01）。在大多数患有抽动和图雷特综合征的病例中，血浆水平为1 - 4纳克/毫升时出现阳性反应，而精神病组未发现相关性。讨论了儿科处方氟哌啶醇时监测血浆药物水平的相关性。
