Albert D J, Walsh M L, Longley W
Behav Neural Biol. 1984 Jul;41(2):127-34. doi: 10.1016/s0163-1047(84)90499-0.
Weanling male hooded rats were handled or not handled for 10 min each day, 5 days/week, for 6 weeks. At the end of this time all animals received one of the following: a septal lesion, a medial accumbens lesion, a medial hypothalamic lesion, or a sham lesion. The animals were tested for defensiveness toward the experimenter on Days 3, 7, and 14 postoperatively. All behavioral testing was done blind. Each of the three lesions increased defensiveness toward the experimenter. However, with each lesion, there was no difference in the defensiveness scores of preoperatively handled and nonhandled animals at any of the postoperative test sessions while those of animals with medial hypothalamic lesions did not. These results are consistent with observations that hyperdefensiveness occurs in human subjects following tumors in each of these brain areas in spite of their familiarity with the situation in which they are observed. They contrast with observations that mouse killing induced by septal lesions is readily prevented by preoperative exposure to a mouse.
将断乳雄性带帽大鼠每周5天，每天处理或不处理10分钟，持续6周。在此时间段结束时，所有动物接受以下操作之一：隔区损伤、伏隔核内侧损伤、下丘脑内侧损伤或假损伤。在术后第3天、第7天和第14天对动物针对实验者的防御性进行测试。所有行为测试均在不知情的情况下进行。三种损伤中的每一种都增加了对实验者的防御性。然而，对于每种损伤，术前处理和未处理的动物在任何术后测试阶段的防御性得分均无差异，而下丘脑内侧损伤的动物则不然。这些结果与以下观察结果一致，即尽管人类受试者熟悉观察他们的情境，但在这些脑区中的每个区域出现肿瘤后，他们都会出现过度防御。它们与以下观察结果形成对比，即术前接触小鼠可轻易预防隔区损伤诱导的杀鼠行为。
