支气管对组胺反应性的长期稳定性
Long-term stability of bronchial responsiveness to histamine.
作者信息
Juniper E F, Frith P A, Hargreave F E
出版信息
Thorax. 1982 Apr;37(4):288-91. doi: 10.1136/thx.37.4.288.
Abstract
Bronchial responsiveness to histamine was measured in 35 adult asthmatics whose symptoms were controlled on a minimum of medication. The tests were carried out on two occasions separated by 10-30 months. On each occasion the subjects had no symptoms of respiratory infection and no exposure to relevant allergens for at least six weeks. Bronchial responsiveness did not change in those who required no medication or inhaled salbutamol only to control their symptoms, but was significantly improved in those who required continuous treatment with both beclomethasone and salbutamol (p = 0.03). The results suggest that non-specific bronchial responsiveness remains similar over long periods when exacerbating factors are not present and that treatment with beclomethasone may reduce hyperresponsiveness.
摘要
对35名成年哮喘患者进行了组胺支气管反应性测定，这些患者的症状通过最少药物得以控制。测试分两次进行，间隔10 - 30个月。每次测试时，受试者均无呼吸道感染症状，且至少六周未接触相关过敏原。对于那些无需用药或仅吸入沙丁胺醇来控制症状的患者，支气管反应性未发生变化，但对于那些需要同时使用倍氯米松和沙丁胺醇进行持续治疗的患者，支气管反应性有显著改善（p = 0.03）。结果表明，在不存在加重因素时，非特异性支气管反应性在长时间内保持相似，且倍氯米松治疗可能会降低高反应性。
相似文献
1
Long-term stability of bronchial responsiveness to histamine.支气管对组胺反应性的长期稳定性
Thorax. 1982 Apr;37(4):288-91. doi: 10.1136/thx.37.4.288.
2
Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma.气道对组胺和乙酰甲胆碱的反应性：与控制哮喘症状的最低治疗的关系。
Thorax. 1981 Aug;36(8):575-9. doi: 10.1136/thx.36.8.575.
3
Airway responsiveness to beta-adrenergic agonist (salbutamol) in asthma.哮喘患者气道对β-肾上腺素能激动剂（沙丁胺醇）的反应性
J Asthma. 2003 Dec;40(8):917-25. doi: 10.1081/jas-120023584.
4
Effect of beclomethasone dipropionate on bronchial responsiveness to histamine in controlled nonsteroid-dependent asthma.丙酸倍氯米松对非激素依赖型哮喘患者支气管组胺反应性的影响
J Allergy Clin Immunol. 1985 Jan;75(1 Pt 1):25-30. doi: 10.1016/0091-6749(85)90007-7.
5
Changes in bronchial reactivity in asthmatic children after treatment with beclomethasone alone or in association with salbutamol.单独使用倍氯米松或与沙丁胺醇联合使用治疗后哮喘儿童支气管反应性的变化。
J Asthma. 1989;26(6):359-64. doi: 10.3109/02770908909073279.
6
Effect of prednisone and beclomethasone dipropionate on airway responsiveness in asthma: a comparative study.泼尼松和二丙酸倍氯米松对哮喘气道反应性的影响：一项比较研究。
Thorax. 1988 May;43(5):378-84. doi: 10.1136/thx.43.5.378.
7
Comparative effects of inhaled salbutamol, sodium cromoglycate, and beclomethasone dipropionate on allergen-induced early asthmatic responses, late asthmatic responses, and increased bronchial responsiveness to histamine.吸入沙丁胺醇、色甘酸钠和二丙酸倍氯米松对变应原诱导的早期哮喘反应、迟发哮喘反应以及支气管对组胺反应性增加的比较效应。
J Allergy Clin Immunol. 1987 May;79(5):734-40. doi: 10.1016/0091-6749(87)90204-1.
8
Effect of therapy on bronchial hyperresponsiveness in the long-term management of asthma.治疗对哮喘长期管理中支气管高反应性的影响。
Clin Allergy. 1988 Mar;18(2):165-76. doi: 10.1111/j.1365-2222.1988.tb02856.x.
9
A comparison of the effects of nedocromil sodium and beclomethasone dipropionate on pulmonary function, symptoms, and bronchial responsiveness in patients with asthma.奈多罗米钠与丙酸倍氯米松对哮喘患者肺功能、症状及支气管反应性影响的比较。
J Allergy Clin Immunol. 1989 Aug;84(2):224-31. doi: 10.1016/0091-6749(89)90329-1.
10
The long-term effects of nedocromil sodium and beclomethasone dipropionate on bronchial responsiveness to methacholine in nonatopic asthmatic subjects.奈多罗米钠和二丙酸倍氯米松对非特应性哮喘患者支气管对乙酰甲胆碱反应性的长期影响。
Am Rev Respir Dis. 1990 Jan;141(1):21-8. doi: 10.1164/ajrccm/141.1.21.
引用本文的文献
1
Precision Medicine and Childhood Asthma: A Guide for the Unwary.精准医学与儿童哮喘：给粗心者的指南。
J Pers Med. 2022 Jan 10;12(1):82. doi: 10.3390/jpm12010082.
2
Asthma: A Loss of Post-natal Homeostatic Control of Airways Smooth Muscle With Regression Toward a Pre-natal State.哮喘：气道平滑肌产后稳态控制丧失，向产前状态回归。
Front Pediatr. 2020 Apr 16;8:95. doi: 10.3389/fped.2020.00095. eCollection 2020.
3
A Brief History of Airway Smooth Muscle's Role in Airway Hyperresponsiveness.气道平滑肌在气道高反应性中作用的简史
J Allergy (Cairo). 2012;2012:768982. doi: 10.1155/2012/768982. Epub 2012 Oct 18.
4
Reproducibility of non-specific bronchial challenge in adults: implications for design, analysis and interpretation of clinical and epidemiological studies.成人非特异性支气管激发试验的可重复性：对临床和流行病学研究的设计、分析及解释的影响
Thorax. 2005 May;60(5):395-400. doi: 10.1136/thx.2004.039230.
5
Effects of corticosteroid inhalation therapy on the deposition pattern of Tc-99m human serum albumin radioaerosols in asthma.吸入性皮质类固醇疗法对哮喘患者中Tc-99m人血清白蛋白放射性气雾剂沉积模式的影响。
Lung. 1995;173(5):291-6. doi: 10.1007/BF00176892.
6
Exercise-induced asthma in athletes.运动员运动诱发的哮喘
Sports Med. 1988 Oct;6(4):193-6. doi: 10.2165/00007256-198806040-00001.
7
Clinical expression of airway hyperreactivity in adults.成人气道高反应性的临床表现
Clin Rev Allergy. 1989 Fall;7(3):321-43. doi: 10.1007/BF02914481.
8
Epidemiology of bronchial hyperresponsiveness.支气管高反应性的流行病学
Clin Rev Allergy. 1989 Fall;7(3):245-56. doi: 10.1007/BF02914477.
9
Bronchial hyperresponsiveness to methacholine in patients with primary Sjögren's syndrome.原发性干燥综合征患者对乙酰甲胆碱的支气管高反应性
Ann Rheum Dis. 1991 Jan;50(1):36-40. doi: 10.1136/ard.50.1.36.
10
Alternative and complementary medicine for asthma.哮喘的替代医学和补充医学
Thorax. 1991 Nov;46(11):787-97. doi: 10.1136/thx.46.11.787.
本文引用的文献
1
[Action of cortisone on the pulmonary cholinergic hypersensitivity of the asthmatic patient].[可的松对哮喘患者肺部胆碱能超敏反应的作用]
Presse Med (1893). 1956 Apr 18;64(31):719-21.
2
Effects of long-term inhaled salbutamol therapy on the provocation of asthma by histamine.长期吸入沙丁胺醇治疗对组胺诱发哮喘的影响。
Am Rev Respir Dis. 1980 Jun;121(6):973-8. doi: 10.1164/arrd.1980.121.6.973.
3
Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma.气道对组胺和乙酰甲胆碱的反应性：与控制哮喘症状的最低治疗的关系。
Thorax. 1981 Aug;36(8):575-9. doi: 10.1136/thx.36.8.575.
4
The effect of corticosteroids on methacholine inhalation in symptomatic bronchial asthma.皮质类固醇对有症状支气管哮喘患者吸入乙酰甲胆碱的影响。
J Allergy. 1968 Apr;41(4):209-16. doi: 10.1016/0021-8707(68)90043-9.
5
Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection.上呼吸道感染后正常受试者支气管高反应性的机制
Am Rev Respir Dis. 1976 Feb;113(2):131-9. doi: 10.1164/arrd.1976.113.2.131.
6
Effect of short-term, low-level nitrogen dioxide exposure on bronchial sensitivity of asthmatic patients.短期低水平二氧化氮暴露对哮喘患者支气管敏感性的影响。
J Clin Invest. 1976 Feb;57(2):301-7. doi: 10.1172/JCI108281.
7
Bronchial reactivity to inhaled histamine: a method and clinical survey.支气管对吸入组胺的反应性：一种方法及临床调查。
Clin Allergy. 1977 May;7(3):235-43. doi: 10.1111/j.1365-2222.1977.tb01448.x.
8
Glucocorticosteroid therapy: mechanisms of action and clinical considerations.糖皮质激素疗法：作用机制与临床考量
Ann Intern Med. 1976 Mar;84(3):304-15. doi: 10.7326/0003-4819-84-3-304.
9
Nonspecific bronchial reactivity in occupational asthma.职业性哮喘中的非特异性支气管反应性
J Allergy Clin Immunol. 1979 Jan;63(1):28-34. doi: 10.1016/0091-6749(79)90158-1.
10
Bronchial hyperirritability in healthy subjects after exposure to ozone.健康受试者暴露于臭氧后出现支气管高反应性。
Am Rev Respir Dis. 1978 Aug;118(2):287-94. doi: 10.1164/arrd.1978.118.2.287.
Zotero 插件