Gudbjörnsson B, Hedenström H, Stålenheim G, Hällgren R
Department of Internal Medicine, Uppsala University Hospital, Sweden.
Ann Rheum Dis. 1991 Jan;50(1):36-40. doi: 10.1136/ard.50.1.36.
The prevalence of bronchial hyperresponsiveness (BHR) to methacholine inhalation in a consecutive series of 21 patients with primary Sjögren's syndrome was studied prospectively. Slight to severe BHR was seen in 12/20 (60%) of the patients. Ten of 12 patients with BHR (83%) had a non-productive cough, wheezing, or intermittent breathlessness. Bronchial hyperresponsiveness was more common in patients with extraglandular symptoms (10/14, 71%) than in those with only glandular symptoms (29%). Spirometrically 29% (6/21) of the patients had 'small airways' disease', and all those had BHR. Of 6/21 (29%) who had diffuse interstitial lung disease, two had BHR. Three of the four patients with obstructive lung function were challenged with methacholine and two of them had BHR. Only two patients with BHR had normal spirometry findings. The data showed that respiratory disease--mostly mild or moderate but even severe bronchial hyperresponsiveness--is commonly seen in patients with primary Sjögren's syndrome.
对连续的21例原发性干燥综合征患者进行前瞻性研究，以探讨吸入乙酰甲胆碱后支气管高反应性（BHR）的患病率。在20例患者中有12例（60%）出现轻度至重度BHR。12例有BHR的患者中有10例（83%）存在干咳、喘息或间歇性气促。腺体外症状患者的支气管高反应性（10/14，71%）比仅出现腺体症状的患者（29%）更为常见。肺功能测定显示，29%（6/21）的患者有“小气道”疾病，所有这些患者均有BHR。在6/21（29%）有弥漫性间质性肺病的患者中，2例有BHR。4例有阻塞性肺功能的患者中有3例接受了乙酰甲胆碱激发试验，其中2例有BHR。只有2例有BHR的患者肺功能测定结果正常。数据表明，呼吸系统疾病——大多为轻度或中度，甚至有严重的支气管高反应性——在原发性干燥综合征患者中很常见。
