慢性阻塞性肺疾病患者压力感受器敏感性降低。
Reduced baroreceptor sensitivity in patients with chronic obstructive pulmonary disease.
作者信息
Patakas D, Louridas G, Kakavelas E
出版信息
Thorax. 1982 Apr;37(4):292-5. doi: 10.1136/thx.37.4.292.
Abstract
Baroreceptor sensitivity, reflected by the slope of the linear regression of the electrocardiographic R-R interval on the rise of systolic blood pressure after injection of phenylephrine, was significantly lower in 27 patients with chronic obstructive pulmonary disease (4.67 +/- 2.67) than in 10 normal subjects (12.07 +/- 3.3) of comparable age (p less than 0.001). In 20 patients in whom right heart catheterisation was performed, pulmonary artery pressure was inversely related to baroreflex sensitivity (r = - 0.603, p less than 0.01). Independent variables such as arterial Po2, Pco2, and mean pulmonary artery pressure were examined in order to assess their ability to predict baroreflex sensitivity. The independent variable that made the most significant contribution was mean pulmonary artery pressure. It seems that the attenuation of baroreflex response in patients with chronic obstructive pulmonary disease is caused mainly by pulmonary hypertension and partly by the central effects of hypoxia and hypercapnia.
摘要
通过注射去氧肾上腺素后收缩压升高时心电图R-R间期的线性回归斜率反映的压力感受器敏感性，在27例慢性阻塞性肺疾病患者（4.67±2.67）中显著低于10名年龄相当的正常受试者（12.07±3.3）（p<0.001）。在20例行右心导管检查的患者中，肺动脉压与压力反射敏感性呈负相关（r=-0.603，p<0.01）。为了评估动脉血氧分压、二氧化碳分压和平均肺动脉压等自变量预测压力反射敏感性的能力，对这些自变量进行了检测。贡献最为显著的自变量是平均肺动脉压。慢性阻塞性肺疾病患者压力反射反应的减弱似乎主要由肺动脉高压引起，部分由缺氧和高碳酸血症的中枢效应所致。
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