慢性阻塞性肺疾病患者压力感受器敏感性降低。
Reduced baroreceptor sensitivity in patients with chronic obstructive pulmonary disease.
作者信息
Patakas D, Louridas G, Kakavelas E
出版信息
Thorax. 1982 Apr;37(4):292-5. doi: 10.1136/thx.37.4.292.
Abstract
Baroreceptor sensitivity, reflected by the slope of the linear regression of the electrocardiographic R-R interval on the rise of systolic blood pressure after injection of phenylephrine, was significantly lower in 27 patients with chronic obstructive pulmonary disease (4.67 +/- 2.67) than in 10 normal subjects (12.07 +/- 3.3) of comparable age (p less than 0.001). In 20 patients in whom right heart catheterisation was performed, pulmonary artery pressure was inversely related to baroreflex sensitivity (r = - 0.603, p less than 0.01). Independent variables such as arterial Po2, Pco2, and mean pulmonary artery pressure were examined in order to assess their ability to predict baroreflex sensitivity. The independent variable that made the most significant contribution was mean pulmonary artery pressure. It seems that the attenuation of baroreflex response in patients with chronic obstructive pulmonary disease is caused mainly by pulmonary hypertension and partly by the central effects of hypoxia and hypercapnia.
摘要
通过注射去氧肾上腺素后收缩压升高时心电图R-R间期的线性回归斜率反映的压力感受器敏感性，在27例慢性阻塞性肺疾病患者（4.67±2.67）中显著低于10名年龄相当的正常受试者（12.07±3.3）（p<0.001）。在20例行右心导管检查的患者中，肺动脉压与压力反射敏感性呈负相关（r=-0.603，p<0.01）。为了评估动脉血氧分压、二氧化碳分压和平均肺动脉压等自变量预测压力反射敏感性的能力，对这些自变量进行了检测。贡献最为显著的自变量是平均肺动脉压。慢性阻塞性肺疾病患者压力反射反应的减弱似乎主要由肺动脉高压引起，部分由缺氧和高碳酸血症的中枢效应所致。
相似文献
1
Reduced baroreceptor sensitivity in patients with chronic obstructive pulmonary disease.慢性阻塞性肺疾病患者压力感受器敏感性降低。
Thorax. 1982 Apr;37(4):292-5. doi: 10.1136/thx.37.4.292.
2
Reduced baroreceptor sensitivity in borderline hypertension.临界高血压患者压力感受器敏感性降低。
Circulation. 1975 Apr;51(4):738-42. doi: 10.1161/01.cir.51.4.738.
3
The effects of raising alveolar PCO2 and ventilation separately and together on the sensitivity and setting of the baroreceptor cardiodepressor reflex in man.分别及共同提高肺泡二氧化碳分压和通气对人体压力感受器心抑制反射敏感性及调定的影响。
J Physiol. 1974 Dec;243(2):401-25. doi: 10.1113/jphysiol.1974.sp010760.
4
Relationship between mechanical properties of the carotid artery wall and baroreflex function in acutely treated hypertensive patients.急性治疗的高血压患者颈动脉壁力学特性与压力反射功能之间的关系。
J Hypertens. 1996 Sep;14(9):1105-10. doi: 10.1097/00004872-199609000-00010.
5
The effects of hypercapnia, hypoxia and ventilation on the baroreflex regulation of the pulse interval.高碳酸血症、低氧血症及通气对脉搏间期压力反射调节的影响。
J Physiol. 1971 Jul;216(2):281-302. doi: 10.1113/jphysiol.1971.sp009525.
6
Alterations in the baroreceptor reflex in conscious dogs with heart failure.清醒心力衰竭犬压力感受器反射的改变。
J Clin Invest. 1972 Apr;51(4):715-24. doi: 10.1172/JCI106865.
7
Baroreflex sensitivity in patients with Takayasu's aortitis.高安动脉炎患者的压力反射敏感性
Circulation. 1977 May;55(5):803-6. doi: 10.1161/01.cir.55.5.803.
8
Valsalva maneuver in the assessment of baroreflex responsiveness in borderline hypertensives.瓦尔萨尔瓦动作在临界高血压患者压力反射反应性评估中的应用
Cardiology. 1983;70(1):6-14. doi: 10.1159/000173563.
9
Interaction of chemoreceptor and baroreceptor reflexes by hypoxia and hypercapnia - a mechanism for promoting hypertension in obstructive sleep apnoea.低氧和高碳酸血症对化学感受器与压力感受器反射的相互作用——一种阻塞性睡眠呼吸暂停中促进高血压的机制
J Physiol. 2005 Oct 15;568(Pt 2):677-87. doi: 10.1113/jphysiol.2005.094151. Epub 2005 Aug 18.
10
Baroreflex sensitivity in renal failure.肾衰竭时的压力感受器反射敏感性
Clin Sci (Lond). 1980 Jan;58(1):21-7. doi: 10.1042/cs0580021.
引用本文的文献
1
Exogenous estradiol increases cardiovagal baroreflex sensitivity during a hypertensive stimulus in premenopausal young women.外源性雌二醇可提高绝经前年轻女性在高血压刺激期间的心血管迷走性压力反射敏感性。
Am J Physiol Heart Circ Physiol. 2025 Aug 1;329(2):H439-H449. doi: 10.1152/ajpheart.00131.2025. Epub 2025 Jul 3.
2
Systemic Manifestations of COPD and the Impact of Dual Bronchodilation with Tiotropium/Olodaterol on Cardiac Function and Autonomic Integrity.慢性阻塞性肺疾病的全身表现以及噻托溴铵/奥达特罗双重支气管扩张对心脏功能和自主神经完整性的影响。
J Clin Med. 2024 May 16;13(10):2937. doi: 10.3390/jcm13102937.
3
Advancements in the neurocirculatory reflex response to hypoxia.神经循环反射对缺氧反应的研究进展。
Am J Physiol Regul Integr Comp Physiol. 2024 Jul 1;327(1):R1-R13. doi: 10.1152/ajpregu.00237.2023. Epub 2024 May 13.
4
Impaired Spontaneous Baroreceptor Reflex Sensitivity in Patients With COPD Compared to Healthy Controls: The Role of Lung Hyperinflation.与健康对照相比，慢性阻塞性肺疾病患者的自发性压力感受器反射敏感性受损：肺过度充气的作用。
Front Med (Lausanne). 2022 Jan 3;8:791410. doi: 10.3389/fmed.2021.791410. eCollection 2021.
5
Effect of Nocturnal Oxygen on Blood Pressure Response to Altitude Exposure in COPD - Data from a Randomized Placebo-Controlled Cross-Over Trial.慢性阻塞性肺疾病患者夜间吸氧对海拔暴露血压反应的影响：一项随机安慰剂对照交叉试验的数据。
Int J Chron Obstruct Pulmon Dis. 2021 Dec 24;16:3503-3512. doi: 10.2147/COPD.S331658. eCollection 2021.
6
Efficacy of Electrical Baroreflex Activation Is Independent of Peripheral Chemoreceptor Modulation.电压力感受反射激活的疗效独立于外周化学感受器的调节。
Hypertension. 2020 Jan;75(1):257-264. doi: 10.1161/HYPERTENSIONAHA.119.13925. Epub 2019 Dec 2.
7
Blood pressure response to exposure to moderate altitude in patients with COPD.COPD 患者暴露于中等海拔高度时的血压反应。
Int J Chron Obstruct Pulmon Dis. 2019 Mar 14;14:659-666. doi: 10.2147/COPD.S194426. eCollection 2019.
8
Chronic obstructive pulmonary disease is independently associated with hypertension in men: A survey design analysis using nationwide survey data.慢性阻塞性肺疾病与男性高血压独立相关：一项使用全国性调查数据的调查设计分析。
Medicine (Baltimore). 2017 May;96(19):e6826. doi: 10.1097/MD.0000000000006826.
9
β-Adrenoceptor modulation in chronic obstructive pulmonary disease: present and future perspectives.β-肾上腺素能受体在慢性阻塞性肺疾病中的调节：现状与未来展望。
Drugs. 2013 Oct;73(15):1653-63. doi: 10.1007/s40265-013-0120-5.
10
Baroreceptor sensitivity after Valsalva maneuver in women with chronic obstructive pulmonary disease.女性慢性阻塞性肺疾病患者瓦尔萨尔瓦动作后的压力感受性反射敏感性。
Clin Auton Res. 2012 Aug;22(4):185-9. doi: 10.1007/s10286-012-0161-y. Epub 2012 Apr 11.
本文引用的文献
1
THE CARDIO-CIRCULATORY EFFECTS IN MAN OF NEO-SYNEPHRIN (1-alpha-hydroxy-beta-methylamino-3-hydroxy-ethylbenzene hydrochloride).新福林（1-α-羟基-β-甲基氨基-3-羟基-乙基苯盐酸盐）对人体的心血管作用
J Clin Invest. 1942 Jan;21(1):1-12. doi: 10.1172/JCI101270.
2
NATURE OF THE INOTROPIC ACTION OF ANGIOTENSIN ON VENTRICULAR MYOCARDIUM.血管紧张素对心室肌的变力作用性质
Circ Res. 1965 Mar;16:230-7. doi: 10.1161/01.res.16.3.230.
3
Aortic blood flow in dogs during treadmill exercise.犬在跑步机运动期间的主动脉血流。
J Appl Physiol. 1959 Sep;14:809-12. doi: 10.1152/jappl.1959.14.5.809.
4
Mechanisms of inhibition of heart rate by phenylephrine.去氧肾上腺素抑制心率的机制。
Circ Res. 1960 Nov;8:1182-6. doi: 10.1161/01.res.8.6.1182.
5
The individual effects of CO2, bicarbonate and pH on the electrical and mechanical activity of isolated rabbit auricles.二氧化碳、碳酸氢盐和pH值对离体兔耳肌电活动和机械活动的单独作用。
J Physiol. 1955 Jul 28;129(1):90-110. doi: 10.1113/jphysiol.1955.sp005340.
6
Relationship between aortic diameter and aortic baroreceptor activity in normal and hypertensive rabbits.正常及高血压兔主动脉直径与主动脉压力感受器活动之间的关系
Acta Physiol Scand. 1969 Mar;75(3):406-14. doi: 10.1111/j.1748-1716.1969.tb04394.x.
7
Effects of carotid sinus nerve stimulation on blood-flow distribution in conscious dogs at rest and during exercise.颈动脉窦神经刺激对清醒犬静息及运动时血流分布的影响。
Circ Res. 1970 Oct;27(4):495-503. doi: 10.1161/01.res.27.4.495.
8
Effects on respiration and circulation of electrically stimulating the ventral surface of the medulla oblongata.电刺激延髓腹侧面对呼吸和循环的影响。
Respir Physiol. 1970 Sep;10(2):184-97. doi: 10.1016/0034-5687(70)90082-4.
9
Effect of age and high blood pressure on baroreflex sensitivity in man.年龄和高血压对人体压力反射敏感性的影响。
Circ Res. 1971 Oct;29(4):424-31. doi: 10.1161/01.res.29.4.424.
10
Impaired reflex vasoconstriction in chronically hypoxemic patients.慢性低氧血症患者反射性血管收缩功能受损。
J Clin Invest. 1972 Feb;51(2):331-7. doi: 10.1172/JCI106818.
Zotero 插件