低剂量聚腺苷酸：聚尿苷酸复合物对小鼠狂犬病疫苗的刺激作用
Stimulation of rabies vaccine in mice by low doses of polyadenylic:polyuridylic complex.
作者信息
Branche R, Renoux G
出版信息
Infect Immun. 1972 Sep;6(3):324-5. doi: 10.1128/iai.6.3.324-325.1972.
Abstract
Addition of 100 mug of polyadenylic: polyuridylic (poly A:U) complex to each dose of inactivated rabies vaccine increased immunity to rabies challenge in mice. Stimulation was also observed after addition of 10 mug of poly A:U to the vaccines. Mixtures of rabies vaccine and poly A:U lost their stimulatory properties after storage at 37 or 4 C for 1 month. However, these data are encouraging for practical use of poly A:U as an adjuvant to viral vaccines.
摘要
每剂灭活狂犬病疫苗中添加100微克聚腺苷酸:聚尿苷酸（poly A:U）复合物可增强小鼠对狂犬病攻击的免疫力。在疫苗中添加10微克poly A:U后也观察到了刺激作用。狂犬病疫苗与poly A:U的混合物在37℃或4℃储存1个月后失去了刺激特性。然而，这些数据对于将poly A:U作为病毒疫苗佐剂的实际应用来说是令人鼓舞的。
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本文引用的文献
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