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[Immunization of ewes against experimental Brucella melitensis infection: comparison of eleven vaccines].[母羊针对实验性羊布鲁氏菌感染的免疫接种：十一种疫苗的比较]
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Biological, biochemical, and physicochemical evidence for the existence of the polyadenylic-polyuridylic-polyinosinic acid triplex.聚腺苷酸-聚尿苷酸-聚肌苷酸三链体存在的生物学、生物化学及物理化学证据。
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8
Genetic control of immune responses to synthetic polypeptides in mice: cellular analysis of the phenotypic correction of the Ir-3 gene defect by polyadenylic-polyuridylic acid.小鼠对合成多肽免疫反应的遗传控制：聚腺苷酸-聚尿苷酸对Ir-3基因缺陷表型校正的细胞分析
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2
The effect of adjuvants and prior immunization on the rate and mode of uptake of antigen into afferent popliteal lymph from sheep.佐剂和预先免疫对绵羊抗原进入腘窝传入淋巴的速率和方式的影响。
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本文引用的文献

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Antibody formation: stimulation by polyadenylic and polycytidylic acids.抗体形成：聚腺苷酸和聚胞苷酸的刺激作用
Science. 1967 Aug 18;157(3790):819-21. doi: 10.1126/science.157.3790.819.
2
INFLUENCE OF OLIGODEOXYRIBONUCLEOTIDES ON EARLY EVENTS IN ANTIBODY FORMATION.寡脱氧核糖核苷酸对抗体形成早期事件的影响
Proc Soc Exp Biol Med. 1965 Jul;119:701-7. doi: 10.3181/00379727-119-30276.
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[Agglutinins and infection in mice due to Brucella melitensis].
Ann Inst Pasteur (Paris). 1968 Dec;115(6):1047-52.
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Biodynamic effects of oligonucleotides.寡核苷酸的生物动力学效应。
Bacteriol Rev. 1967 Jun;31(2):83-94. doi: 10.1128/br.31.2.83-94.1967.
5
Regulation of the immune system by synthetic polynucleotides. 3. Action on antigen-reactive cells of thymic origin.合成多核苷酸对免疫系统的调节作用。3. 对胸腺来源的抗原反应性细胞的作用。
J Exp Med. 1971 Mar 1;133(3):665-76. doi: 10.1084/jem.133.3.665.
6
Cyclic AMP effects on antibody formation and their similarities to hormone-mediated events.
Proc Soc Exp Biol Med. 1970 Sep;134(4):963-7. doi: 10.3181/00379727-134-34921.

聚腺苷酸：聚尿苷酸复合物对小鼠抗菌疫苗接种的刺激作用。

Stimulation of antibacterial vaccination in mice by polyadenylic acid: polyuridylic acid complex.

作者信息

Renoux G, Renoux M, Branche R

出版信息

Infect Immun. 1972 Nov;6(5):699-702. doi: 10.1128/iai.6.5.699-702.1972.

DOI:10.1128/iai.6.5.699-702.1972
PMID:4637296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422596/
Abstract

The effect of polyadenylic acid:polyuridylic acid complex (poly A:U) on immunization was investigated in mice vaccinated by killed Brucella melitensis cells suspended in incomplete adjuvant or in saline. Addition of 300 mug of poly A:U to vaccines rendered 3 x 10(8)B. melitensis cells in saline as immunogenic as 3 x 10(11) cells in oil adjuvant against a severe B. abortus challenge. In the mouse and Brucella system, poly A:U exerts an adjuvant effect on immunity but does not stimulate production of circulating antibodies that could be demonstrated at the time of autopsy.

摘要

研究了聚腺苷酸

聚尿苷酸复合物（poly A:U）对用悬浮于不完全佐剂或盐水中的灭活羊种布鲁氏菌细胞进行免疫接种的小鼠的免疫作用。向疫苗中添加300微克的poly A:U，可使盐水中3×10⁸个羊种布鲁氏菌细胞的免疫原性与油佐剂中3×10¹¹个细胞的免疫原性相当，以抵抗严重的流产布鲁氏菌攻击。在小鼠和布鲁氏菌系统中，poly A:U对免疫发挥佐剂作用，但不刺激在尸检时可检测到的循环抗体的产生。