聚腺苷酸：聚尿苷酸复合物对小鼠抗菌疫苗接种的刺激作用。
Stimulation of antibacterial vaccination in mice by polyadenylic acid: polyuridylic acid complex.
作者信息
Renoux G, Renoux M, Branche R
出版信息
Infect Immun. 1972 Nov;6(5):699-702. doi: 10.1128/iai.6.5.699-702.1972.
The effect of polyadenylic acid:polyuridylic acid complex (poly A:U) on immunization was investigated in mice vaccinated by killed Brucella melitensis cells suspended in incomplete adjuvant or in saline. Addition of 300 mug of poly A:U to vaccines rendered 3 x 10(8)B. melitensis cells in saline as immunogenic as 3 x 10(11) cells in oil adjuvant against a severe B. abortus challenge. In the mouse and Brucella system, poly A:U exerts an adjuvant effect on immunity but does not stimulate production of circulating antibodies that could be demonstrated at the time of autopsy.
研究了聚腺苷酸
聚尿苷酸复合物（poly A:U）对用悬浮于不完全佐剂或盐水中的灭活羊种布鲁氏菌细胞进行免疫接种的小鼠的免疫作用。向疫苗中添加300微克的poly A:U，可使盐水中3×10⁸个羊种布鲁氏菌细胞的免疫原性与油佐剂中3×10¹¹个细胞的免疫原性相当，以抵抗严重的流产布鲁氏菌攻击。在小鼠和布鲁氏菌系统中，poly A:U对免疫发挥佐剂作用，但不刺激在尸检时可检测到的循环抗体的产生。
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