Ljunghall S, Akerström G
Urol Int. 1982;37(2):73-8. doi: 10.1159/000280800.
Urate metabolism was studied in 40 patients with primary hyperparathyroidism (HPT), 20 of them had a history of renal stones. Preoperatively they had, compared to controls, a reduction of the clearance of urate and a rise of the serum urate concentrations. These disturbances were normalized postoperatively. HPT patients, in particular those with a history of stones, had a high urinary calcium excretion probably as a result of both increased bone resorption and intestinal calcium uptake. There was a close relationship between the urinary urate and calcium excretions preoperatively but not after surgery. There were no consistent differences with regard to urate metabolism in the stone-forming individuals with HPT as compared to those who had never formed a renal stone and thus it seems unlikely that disturbances of urate handling are of any particular importance for the well-known propensity to form stones in primary HPT.
对40例原发性甲状旁腺功能亢进症（HPT）患者的尿酸代谢进行了研究，其中20例有肾结石病史。术前与对照组相比，他们的尿酸清除率降低，血清尿酸浓度升高。这些紊乱在术后恢复正常。HPT患者，尤其是有结石病史的患者，尿钙排泄量较高，这可能是骨吸收增加和肠道钙吸收增加共同作用的结果。术前尿酸排泄与钙排泄之间存在密切关系，但术后不存在这种关系。与从未形成过肾结石的患者相比，有HPT的结石形成个体在尿酸代谢方面没有一致的差异，因此尿酸处理紊乱似乎对原发性HPT中众所周知的结石形成倾向没有特别重要的影响。
