Drach G W
J Urol. 1976 Sep;116(3):338-40. doi: 10.1016/s0022-5347(17)58808-4.
Investigation of multiple serum and urinary factors in 44 patients with calcium urinary stone disease confirmed a number of defects that have been described previously: elevation of mean serum calcium and uric acid above normal, and depression of mean serum magnesium. Urinary excretion of calcium and uric acid was increased and was increased and was probably related to food ingestion. Urinary magnesium also increased after eating but less than calcium, with the result that for most patients the magnesium to calcium x 100 ratio approached levels observed in stone formation. Urinary oxalate excretion was constant during the entire observation period and apparently was not affected by ingestion of a defined diet. Nine additional patients had persistent hypercalcemia owing to hyperparathyroidism (5 confirmed, 1 suspected), malignancy (2) and drug ingestion (1). Metabolic evaluation of patients with calcium urinary calculi continues to contribute to decisions regarding their best therapeutic regimen.
对44例钙尿石病患者的多种血清和尿液因素进行研究，证实了一些先前已描述的缺陷：平均血清钙和尿酸高于正常水平，平均血清镁降低。钙和尿酸的尿排泄量增加，且可能与食物摄入有关。进食后尿镁也增加，但低于钙，结果是大多数患者镁与钙的×100比值接近结石形成时观察到的水平。在整个观察期内尿草酸盐排泄量恒定，显然不受特定饮食摄入的影响。另外9例患者因甲状旁腺功能亢进（5例确诊，1例疑似）、恶性肿瘤（2例）和药物摄入（1例）而持续高钙血症。对钙尿石患者的代谢评估继续有助于决定其最佳治疗方案。
