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[七烯抗生素左菌素的氧化破坏]

[Oxidative destruction of the heptaene antibiotic levorin].

作者信息

Severinets L Ia, Ivanova I A, Rodichev A G, Krunchak V G, Komarov E V

出版信息

Antibiotiki. 1983 Jul;28(7):497-502.

PMID:6625544
Abstract

Levorin destruction in oxygen, argon or air at various temperature levels was studied. It was found that destruction of the antibiotic molecule was mainly due to its interaction with oxygen. As a result the heptaenic chromophore was oxidized and triene and tetraene formed. Oxidation of levorin was accompanied by splitting out of paraaminoacetophenone. Destruction of levorin in the absence of oxygen was retarded.

摘要

研究了利佛菌素在不同温度水平的氧气、氩气或空气中的破坏情况。发现抗生素分子的破坏主要是由于其与氧气的相互作用。结果,七烯发色团被氧化,形成了三烯和四烯。利佛菌素的氧化伴随着对氨基苯乙酮的分解。在无氧条件下利佛菌素的破坏受到抑制。

相似文献

1
[Oxidative destruction of the heptaene antibiotic levorin].[七烯抗生素左菌素的氧化破坏]
Antibiotiki. 1983 Jul;28(7):497-502.
2
[Inactivation mechanism of polyene antibiotics. The change in the functional component of levorin during inactivation].[多烯抗生素的失活机制。左菌素失活过程中功能成分的变化]
Antibiotiki. 1980 Aug;25(8):566-71.
3
[Mechanism of polyene antibiotic inactivation. Possible ways for levorin stabilization].
Antibiotiki. 1982 Aug;27(8):585-8.
4
[Mechanism of polyene antibiotic inactivation. The effect of amino sugar oxidation on polyene chain destruction].[多烯抗生素失活机制。氨基糖氧化对多烯链破坏的影响]
Antibiotiki. 1982 Jun;27(6):430-4.
5
[Polyene antibiotics stability, study of the rate of the heterogeneous destruction of the hepataene antibiotic levorin by an "accelerated aging" method and the possibility of predicting the shelf life of levorin].[多烯抗生素稳定性,通过“加速老化”方法研究肝多烯抗生素左菌素的非均相破坏速率以及预测左菌素保质期的可能性]
Antibiotiki. 1982 Apr;27(4):269-75.
6
The complete stereochemistry of the antibiotic candicidin A3 (syn. ascosin A3, levorin A3).抗生素坎地辛 A3(同义词:ascosin A3,左旋菌素 A3)的全立体化学。
Nat Prod Res. 2020 Oct;34(20):2869-2879. doi: 10.1080/14786419.2019.1596095. Epub 2019 Apr 9.
7
Comparison of candicidin, levorin and trichomycin by means of high-performance liquid chromatography.通过高效液相色谱法比较杀假丝菌素、左霉素和抗滴虫霉素。
J Chromatogr. 1976 Jul 21;123(1):205-11. doi: 10.1016/s0021-9673(00)81116-4.
8
[Mechanism of polyene antibiotic inactivation. Changes in the physicochemical characteristics and the destruction of the polyene chromophore levorin during inactivation].[多烯抗生素失活机制。失活过程中多烯发色团左旋菌素的物理化学特性变化及破坏]
Antibiotiki. 1982;27(7):496-501.
9
[Formation of peroxide compounds and their role in the inactivation of polyene antibiotics levorin and mycoheptin].[过氧化物化合物的形成及其在多烯抗生素左菌素和霉菌肝菌素失活中的作用]
Antibiotiki. 1977 Nov;22(11):977-81.
10
[Isomerization of levorin. The structure of isolevorin A2].[左菌素的异构化。异左菌素A2的结构]
Antibiot Med Biotekhnol. 1987 May;32(5):333-7.