Rutledge R, Baker V V, Sherertz R, Johnson G
Arch Surg. 1982 Sep;117(9):1164-5. doi: 10.1001/archsurg.1982.01380330028008.
We investigated rifampin and cefazolin sodium as prophylactic agents in a dog model of vascular graft infection. A 1-cm segment of 3-mm-diameter polytetrafluoroethylene (Gore-tex) graft was sewn into the right carotid artery of each dog, and prior to closure, 10(3) Staphylococcus organisms sensitive to both cefazolin and rifampin were injected over the graft. The dogs were killed five days after surgery and the grafts cultured. Infection occurred in 100% of controls, 58% of cefazolin-pretreated dogs, and 17% of rifampin-pretreated dogs. Mean blood levels of antibiotics were assayed as follows: cefazolin, 50.1 micrograms/mL; rifampin, 2.9 micrograms/mL. Both were well above the minimal inhibitory concentration. Thus, rifampin proved to be more effective than cefazolin in this animal model.
我们在犬类血管移植感染模型中研究了利福平与头孢唑林钠作为预防药物的效果。将一段1厘米长、直径3毫米的聚四氟乙烯（戈尔特斯）移植物缝入每只犬的右颈动脉，在缝合前，将对头孢唑林和利福平均敏感的10³ 个葡萄球菌注入移植物上方。术后五天处死犬只并对移植物进行培养。对照组感染率为100%，头孢唑林预处理组犬只感染率为58%，利福平预处理组犬只感染率为17%。抗生素平均血药浓度测定如下：头孢唑林为50.1微克/毫升；利福平为2.9微克/毫升。两者均远高于最低抑菌浓度。因此，在该动物模型中，利福平被证明比头孢唑林更有效。
