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Long-term maintenance and induction of cytochrome P-450 in primary cultures of rat hepatocytes.

作者信息

Nelson K F, Acosta D, Bruckner J V

出版信息

Biochem Pharmacol. 1982 Jun 15;31(12):2211-4. doi: 10.1016/0006-2952(82)90521-4.

DOI:10.1016/0006-2952(82)90521-4
PMID:7115442
Abstract
摘要

相似文献

1
Long-term maintenance and induction of cytochrome P-450 in primary cultures of rat hepatocytes.大鼠肝细胞原代培养物中细胞色素P - 450的长期维持与诱导
Biochem Pharmacol. 1982 Jun 15;31(12):2211-4. doi: 10.1016/0006-2952(82)90521-4.
2
Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response.苯巴比妥对细胞色素P - 450的诱导作用。原代大鼠肝细胞培养物对药物诱导的高水平长期反应性，以及苯巴比妥反应的糖皮质激素依赖性。
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3
Dependence of the induction of cytochrome P-450 by phenobarbital in primary cultures of adult rat hepatocytes on the composition of the culture medium.
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Multiplicity of hepatic cytochrome P-450 in intact microsomes: effect of phenobarbital induction.
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Response of NADPH cytochrome c reductase and cytochrome P-450 in hepatic microsomes to treatment with phenobarbital--differences in rat strains.肝微粒体中NADPH细胞色素c还原酶和细胞色素P - 450对苯巴比妥处理的反应——大鼠品系间的差异
Biochem Pharmacol. 1975 Nov 15;24(22):2105-6. doi: 10.1016/0006-2952(75)90112-4.
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Induction of cytochromes P-450b/e by phenobarbital in primary culture of adult rat hepatocytes: test of differentiated liver gene expression.苯巴比妥对成年大鼠肝细胞原代培养物中细胞色素P-450b/e的诱导：分化肝脏基因表达的检测
Drug Metab Rev. 1989;20(2-4):793-809. doi: 10.3109/03602538909103579.
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Comparison of cytochrome P450 isoenzyme profiles in rat liver and hepatocyte cultures. The effects of model inducers on apoproteins and biotransformation activities.大鼠肝脏和肝细胞培养物中细胞色素P450同工酶谱的比较。模型诱导剂对载脂蛋白和生物转化活性的影响。
Biochem Pharmacol. 1991 Jul 5;42(2):381-90. doi: 10.1016/0006-2952(91)90726-l.
8
Immunological evidence for phenobarbital-stimulated synthesis of cytochrome P-450 in primary cultures of chick embryo hepatocytes.苯巴比妥刺激鸡胚肝细胞原代培养物中细胞色素P-450合成的免疫学证据。
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[Induction of cytochrome P-450 forms in liver microsomes of rats in the early neonatal period after administration of phenobarbital and 3-methylcholanthrene].[苯巴比妥和3-甲基胆蒽给药后新生大鼠早期肝脏微粒体中细胞色素P-450亚型的诱导]
Biokhimiia. 1985 Nov;50(11):1817-24.
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Differences in cytochrome P-450 levels between isolated hepatocytes and hepatic microsomes from phenobarbital treated rats.苯巴比妥处理的大鼠分离肝细胞与肝微粒体之间细胞色素P - 450水平的差异。
Riv Eur Sci Med Farmacol. 1987 Jun;9(2):129-31.

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models for liver toxicity testing.肝毒性测试模型
Toxicol Res (Camb). 2013 Jan 1;2(1):23-39. doi: 10.1039/C2TX20051A. Epub 2012 Nov 23.
3
An in vitro approach to the study of target organ toxicity of drugs and chemicals.一种研究药物和化学物质靶器官毒性的体外方法。
In Vitro Cell Dev Biol. 1985 Sep;21(9):495-504. doi: 10.1007/BF02620841.
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The effect of oxygen tension on rat hepatocytes in short-term culture.
In Vitro Cell Dev Biol. 1987 May;23(5):332-8. doi: 10.1007/BF02620989.
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New functional cell-culture approach to pulmonary carcinogenesis and toxicology.用于肺癌发生和毒理学研究的新型功能性细胞培养方法。
J Cancer Res Clin Oncol. 1990;116(6):557-62. doi: 10.1007/BF01637074.
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Cell culture systems and in vitro toxicity testing. Technical report no. 4 of the Johns Hopkins Center for Alternatives to Animal Testing (CAAT): technical workshop of June 13-15, 1990.细胞培养系统与体外毒性测试。约翰霍普金斯大学动物实验替代方法中心（CAAT）技术报告第4号：1990年6月13 - 15日技术研讨会。
Cytotechnology. 1992;8(2):129-76.