L-丙氨酸对体外生酮作用的影响。
Effects of L-alanine on ketogenesis in vitro.
作者信息
Sugden M C, Watts D I
出版信息
Biochim Biophys Acta. 1982 Aug 6;717(2):385-6. doi: 10.1016/0304-4165(82)90193-3.
PMID:7115774
Abstract
Alanine (5 mM) increased 14CO2 production from [1-14C]oleate by 130% and from [1-14C]butyrate by 101%. Alanine inhibited ketone-body production by 37.5% in the presence of butyrate but did not affect ketogenesis in the presence of oleate. Alanine decreased the [3-hydroxybutyrate]/[acetoacetate] ratio when either butyrate or oleate was present. The results are discussed with reference to the hypoketonaemic action of alanine in vivo.
摘要
丙氨酸（5毫摩尔）使[1-¹⁴C]油酸酯产生¹⁴CO₂的量增加了130%，使[1-¹⁴C]丁酸酯产生¹⁴CO₂的量增加了101%。在存在丁酸的情况下，丙氨酸使酮体生成减少了37.5%，但在存在油酸的情况下不影响酮生成。当存在丁酸或油酸时，丙氨酸降低了[3-羟基丁酸]/[乙酰乙酸]的比值。结合丙氨酸在体内的低酮血症作用对结果进行了讨论。
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