Williamson D H, Ilic V, Tordoff A F, Ellington E V
Biochem J. 1980 Feb 15;186(2):621-4. doi: 10.1042/bj1860621.
Vasopressin (10nM) inhibited ketogenesis (56%) in hepatocytes from fed rats when oleate (1 mM) was the substrate, but had no effect with butyrate (10mM). The hormone increased the accumulation of lactate and stimulated the esterification of [1(-14)C]oleate (70%). These effects of vasopressin were reversed by glucagon (10 nM). The physiological implications of these findings are discussed.
当以油酸盐(1毫摩尔)为底物时,血管加压素(10纳摩尔)抑制了喂食大鼠肝细胞中的生酮作用(56%),但对丁酸盐(10毫摩尔)则无影响。该激素增加了乳酸的积累,并刺激了[1(-14)C]油酸盐的酯化作用(70%)。血管加压素的这些作用被胰高血糖素(10纳摩尔)逆转。本文讨论了这些发现的生理学意义。