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1
Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats.血管升压素与胰高血糖素对喂食大鼠分离肝细胞中酮体生成和油酸代谢的相互作用。
Biochem J. 1980 Feb 15;186(2):621-4. doi: 10.1042/bj1860621.
2
Alpha 1-adrenergic regulation of ketogenesis in isolated rat hepatocytes.α1-肾上腺素能对分离的大鼠肝细胞中酮体生成的调节
Biochim Biophys Acta. 1991 Mar 19;1092(1):94-100. doi: 10.1016/0167-4889(91)90182-w.
3
Effects of lactation of ketogenesis from oleate or butyrate in rat hepatocytes.大鼠肝细胞中油酸或丁酸生酮作用的泌乳效应。
Biochem J. 1977 Jun 15;164(3):521-8. doi: 10.1042/bj1640521.
4
The fuel of respiration of rat kidney cortex.大鼠肾皮质呼吸的燃料。
Biochem J. 1969 Apr;112(2):149-66. doi: 10.1042/bj1120149.
5
Hormonal regulation of ketogenesis in hepatocytes from fed rats before and after glycogen depletion.糖原耗竭前后喂食大鼠肝细胞中酮体生成的激素调节。
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6
Effects of exogenous phospholipase enzymes, arachidonic acid and 1-oleoyl-2-acetyl-sn-glycerol on ketogenesis in isolated rat hepatocytes.外源性磷脂酶、花生四烯酸和1-油酰基-2-乙酰基-sn-甘油对分离的大鼠肝细胞生酮作用的影响。
Biochim Biophys Acta. 1989 Jun 15;1012(1):5-9. doi: 10.1016/0167-4889(89)90003-7.
7
Effects of L-alanine on ketogenesis in vitro.L-丙氨酸对体外生酮作用的影响。
Biochim Biophys Acta. 1982 Aug 6;717(2):385-6. doi: 10.1016/0304-4165(82)90193-3.
8
Effects of vasopressin, angiotensin II and phenylephrine on hepatic ketogenesis and fatty acid synthesis.血管加压素、血管紧张素II和去氧肾上腺素对肝脏生酮作用及脂肪酸合成的影响。
Jpn J Pharmacol. 1986 Aug;41(4):525-32. doi: 10.1254/jjp.41.525.
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Can isolated spans of the tricarboxylic acid cycle operate independently? L-proline, oleate and butyrate metabolism in rat hepatocytes.三羧酸循环的孤立片段能独立运作吗？大鼠肝细胞中L-脯氨酸、油酸酯和丁酸盐的代谢
Biochem Int. 1983 Apr;6(4):433-41.
10
Evidence for a reciprocal relationship between lipogenesis and ketogenesis in hepatocytes from fed virgin and lactating rats.关于进食状态下未孕大鼠和泌乳大鼠肝细胞中脂肪生成与酮体生成之间相互关系的证据。
Biochem J. 1978 Oct 15;176(1):331-4. doi: 10.1042/bj1760331.

引用本文的文献

1
Impairment of effects of vasopressin on [1-14C]oleate metabolism in hepatocytes from obese (ob/ob) mice.肥胖（ob/ob）小鼠肝细胞中血管加压素对[1-14C]油酸代谢作用的损害。
Biochem J. 1981 Jul 15;198(1):239-42. doi: 10.1042/bj1980239.
2
Role of glycerol 3-phosphate and glycerophosphate acyltransferase in the nutritional control of hepatic triacylglycerol synthesis.3-磷酸甘油和甘油磷酸酰基转移酶在肝脏三酰甘油合成营养调控中的作用
Biochem J. 1982 Apr 15;204(1):247-56. doi: 10.1042/bj2040247.
3
Glucagon inhibits triacylglycerol synthesis in isolated hepatocytes by lowering their glycerol 3-phosphate content.胰高血糖素通过降低离体肝细胞中3-磷酸甘油的含量来抑制三酰甘油的合成。
Biochem J. 1982 Mar 15;202(3):803-6. doi: 10.1042/bj2020803.
4
The effects of orthovanadate on fatty acid synthesis in isolated rat hepatocytes.原钒酸盐对分离的大鼠肝细胞中脂肪酸合成的影响。
Biochem J. 1982 Mar 15;202(3):791-4. doi: 10.1042/bj2020791.
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Phosphatidylinositol metabolism in rat hepatocytes stimulated by vasopressin.血管加压素刺激下大鼠肝细胞中的磷脂酰肌醇代谢
Biochem J. 1981 Jan 15;194(1):155-65. doi: 10.1042/bj1940155.
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Mechanism for the 'anti-lipolytic' action of vasopressin in the starved rat.血管加压素对饥饿大鼠的“抗脂解”作用机制。
Biochem J. 1983 Jun 15;212(3):899-902. doi: 10.1042/bj2120899.
7
A transient increase in diacylglycerols is associated with the action of vasopressin on hepatocytes.二酰基甘油的短暂增加与血管加压素对肝细胞的作用有关。
Biochem J. 1984 Sep 1;222(2):535-40. doi: 10.1042/bj2220535.
8
Stimulation of glycolysis and accumulation of a stimulator of phosphofructokinase in hepatocytes incubated with vasopressin.用血管加压素孵育肝细胞时，糖酵解的刺激及磷酸果糖激酶刺激物的积累。
Biochem J. 1981 Mar 15;194(3):1023-6. doi: 10.1042/bj1941023.
9
Stimulation of [1-14C]oleate oxidation to 14CO2 in isolated rat hepatocytes by the catecholamines, vasopressin and angiotensin. A possible mechanism of action.儿茶酚胺、血管加压素和血管紧张素对离体大鼠肝细胞中[1-14C]油酸氧化生成14CO2的刺激作用。一种可能的作用机制。
Biochem J. 1983 Apr 15;212(1):85-91. doi: 10.1042/bj2120085.
10
Effects of vasopressin and corticosterone on fatty acid metabolism and on the activities of glycerol phosphate acyltransferase and phosphatidate phosphohydrolase in rat hepatocytes.血管加压素和皮质酮对大鼠肝细胞脂肪酸代谢以及磷酸甘油酰基转移酶和磷脂酸磷酸水解酶活性的影响。
Biochem J. 1984 Jan 15;217(2):461-9. doi: 10.1042/bj2170461.

本文引用的文献

1
[On the metabolite content and the metabolite concentration in the liver of the rat].[关于大鼠肝脏中的代谢物含量及代谢物浓度]
Biochem Z. 1959;332:18-46.
2
Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.血液中D(-)-β-羟基丁酸和乙酰乙酸的酶法测定
Biochem J. 1962 Jan;82(1):90-6. doi: 10.1042/bj0820090.
3
Control of gluconeogenesis in liver. II. Effects of glucagon, catecholamines, and adenosine 3',5'-monophosphate on gluconeogenesis in the perfused rat liver.肝脏中糖异生的调控。II. 胰高血糖素、儿茶酚胺和3',5'-环磷酸腺苷对灌注大鼠肝脏中糖异生的影响。
J Biol Chem. 1968 Aug 25;243(16):4189-96.
4
High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.大鼠肝脏实质细胞分离的高效制备：生化与精细结构研究
J Cell Biol. 1969 Dec;43(3):506-20. doi: 10.1083/jcb.43.3.506.
5
Vasopressin clearance and secretion during haemorrhage in normal dogs and in dogs with experimental diabetes insipidus.正常犬和实验性尿崩症犬在出血期间的血管加压素清除率与分泌情况
J Physiol. 1972 Dec;227(2):395-418. doi: 10.1113/jphysiol.1972.sp010039.
6
Inhibition of fatty acid synthesis and stimulation of glycogen breakdown by vasopressin in the perfused mouse liver.血管加压素对灌注小鼠肝脏中脂肪酸合成的抑制作用及对糖原分解的刺激作用。
Biochem J. 1975 Nov;152(2):389-92. doi: 10.1042/bj1520389.
7
Metabolic actions of vasopressin, glucagon and adrenalin in the intact rat.血管加压素、胰高血糖素和肾上腺素在正常大鼠体内的代谢作用。
Biochim Biophys Acta. 1975 Nov 10;411(1):155-64. doi: 10.1016/0304-4165(75)90294-9.
8
Effects of lactation of ketogenesis from oleate or butyrate in rat hepatocytes.大鼠肝细胞中油酸或丁酸生酮作用的泌乳效应。
Biochem J. 1977 Jun 15;164(3):521-8. doi: 10.1042/bj1640521.
9
Effect of glucagon on hepatic malonyl coenzyme A concentration and on lipid synthesis.胰高血糖素对肝脏丙二酰辅酶A浓度及脂质合成的影响。
J Biol Chem. 1977 Jun 25;252(12):4421-4.
10
Branched-chain amino acids, nitrogen excretion and injury in man.支链氨基酸、氮排泄与人体损伤
Clin Sci Mol Med. 1976 May;50(5):393-9. doi: 10.1042/cs0500393.

血管升压素与胰高血糖素对喂食大鼠分离肝细胞中酮体生成和油酸代谢的相互作用。

Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats.

作者信息

Williamson D H, Ilic V, Tordoff A F, Ellington E V

出版信息

Biochem J. 1980 Feb 15;186(2):621-4. doi: 10.1042/bj1860621.

DOI:10.1042/bj1860621
PMID:7378069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1161618/
Abstract

Vasopressin (10nM) inhibited ketogenesis (56%) in hepatocytes from fed rats when oleate (1 mM) was the substrate, but had no effect with butyrate (10mM). The hormone increased the accumulation of lactate and stimulated the esterification of [1(-14)C]oleate (70%). These effects of vasopressin were reversed by glucagon (10 nM). The physiological implications of these findings are discussed.

摘要

当以油酸盐（1毫摩尔）为底物时，血管加压素（10纳摩尔）抑制了喂食大鼠肝细胞中的生酮作用（56%），但对丁酸盐（10毫摩尔）则无影响。该激素增加了乳酸的积累，并刺激了[1(-14)C]油酸盐的酯化作用（70%）。血管加压素的这些作用被胰高血糖素（10纳摩尔）逆转。本文讨论了这些发现的生理学意义。