血管升压素与胰高血糖素对喂食大鼠分离肝细胞中酮体生成和油酸代谢的相互作用。
Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats.
作者信息
Williamson D H, Ilic V, Tordoff A F, Ellington E V
出版信息
Biochem J. 1980 Feb 15;186(2):621-4. doi: 10.1042/bj1860621.
Abstract
Vasopressin (10nM) inhibited ketogenesis (56%) in hepatocytes from fed rats when oleate (1 mM) was the substrate, but had no effect with butyrate (10mM). The hormone increased the accumulation of lactate and stimulated the esterification of [1(-14)C]oleate (70%). These effects of vasopressin were reversed by glucagon (10 nM). The physiological implications of these findings are discussed.
摘要
当以油酸盐（1毫摩尔）为底物时，血管加压素（10纳摩尔）抑制了喂食大鼠肝细胞中的生酮作用（56%），但对丁酸盐（10毫摩尔）则无影响。该激素增加了乳酸的积累，并刺激了[1(-14)C]油酸盐的酯化作用（70%）。血管加压素的这些作用被胰高血糖素（10纳摩尔）逆转。本文讨论了这些发现的生理学意义。
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