Wallace R B, Das G D
Brain Res. 1982 Jul 8;243(1):133-9. doi: 10.1016/0006-8993(82)91126-x.
Embryonic forebrain tissue from 17-day embryos was transplanted into the midline cerebellum of 10-day-old rat pups. The animals were allowed to survive for behavioral testing and were compared with animals receiving aspiration lesions of midline cerebellum and with normal controls. Subsequent histology indicated that the transplanted tissue had produced a compression lesion of the host cerebellum and had become fully integrated with the neuropil of the host animal. Behavioral results revealed no significant differences between transplant and control animals. Both of these groups were discriminably different from the lesion condition. It is suggested that the transplant may establish afferent and efferent connections similar to those present in the intact animal and thus may be anatomically well integrated with the host brain.
将17日龄胚胎的前脑组织移植到10日龄幼鼠的中线小脑。让这些动物存活以进行行为测试，并与接受中线小脑抽吸损伤的动物和正常对照进行比较。随后的组织学检查表明，移植的组织对宿主小脑产生了压迫性损伤，并已与宿主动物的神经纤维网完全整合。行为结果显示移植动物和对照动物之间没有显著差异。这两组与损伤组均有明显不同。有人提出，移植可能建立了与完整动物中相似的传入和传出连接，因此在解剖学上可能与宿主脑很好地整合。
