新型抗生素烯胺霉素A、B和C。III. 烯胺霉素A、B和C的结构。

New antibiotics, enaminomycins A, B and C. III. The structures of enaminomycins A, B and C.

作者信息

Itoh Y, Haneishi T, Arai M, Hata T, Aiba K, Tamura C

出版信息

J Antibiot (Tokyo). 1978 Sep;31(9):838-46. doi: 10.7164/antibiotics.31.838.

DOI:10.7164/antibiotics.31.838

Abstract

The structures of enaminomycins A and B were determined by their physico-chemical properties and X-ray crystallographic analyses to be 4-amino-2,5-dioxo-7-oxa-bicyclo[4,1,0]hept-3-ene-3-carboxylic acid and 2-oxo-4-amino-5-hydroxy-5-acetonyl-7-oxa-bicyclo[4,1,0]hept-3-ene-3-carboxylic acid, respectively. The structure of enaminomycin C was also determined by the analysis of NMR spectrum and other physico-chemical properties to be 2-oxo-4-amino-5-hydroxy-7-oxa-bicyclo[4,1,0]hept-3-ene-3-carboxylic acid.

摘要

通过物理化学性质和X射线晶体学分析确定，烯胺霉素A和B的结构分别为4-氨基-2,5-二氧代-7-氧杂双环[4,1,0]庚-3-烯-3-羧酸和2-氧代-4-氨基-5-羟基-5-乙酰基-7-氧杂双环[4,1,0]庚-3-烯-3-羧酸。通过核磁共振光谱分析和其他物理化学性质也确定了烯胺霉素C的结构为2-氧代-4-氨基-5-羟基-7-氧杂双环[4,1,0]庚-3-烯-3-羧酸。