Stierer M, Rosen H, Weber R, Hanak H, Auerbach L, Spona J, Tüchler H
Hanusch Medical Center, Department of Surgery, Vienna, Austria.
Breast Cancer Res Treat. 1995;36(1):11-21. doi: 10.1007/BF00690180.
The immunohistochemically determined receptor status, as well as first-generation risk factors (tumor size, lymph node status, histologic grading including subfactors, tumor histology, and biochemically determined receptor status) were prospectively analyzed in 288 cases of primary breast cancer for their impact on recurrence-free survival (RFS) and overall survival (OS) after a median observation period of 41 months. Immunohistochemically (ER-ICA) and biochemically determined estrogen receptors (ER-DCC), as well as tumor size, lymph node status, histologic grading, mitotic rate, and nuclear polymorphism, were of prognostic value for recurrence-free survival and/or overall survival. In multivariate analysis, lymph node status, tumor size, and mitotic rate proved to be independent prognosticators; ER-ICA showed significance in the univariate analysis which dropped, however, when multivariate analysis was applied. The prognostic power of histologic grading in our series seemed to depend mainly on the subfactors which relate to nuclear features.
对288例原发性乳腺癌患者进行前瞻性分析，研究免疫组化确定的受体状态以及第一代风险因素（肿瘤大小、淋巴结状态、包括子因素的组织学分级、肿瘤组织学和生化确定的受体状态）在中位观察期41个月后对无复发生存期（RFS）和总生存期（OS）的影响。免疫组化（ER-ICA）和生化确定的雌激素受体（ER-DCC），以及肿瘤大小、淋巴结状态、组织学分级、有丝分裂率和核多态性，对无复发生存期和/或总生存期具有预后价值。在多变量分析中，淋巴结状态、肿瘤大小和有丝分裂率被证明是独立的预后因素；ER-ICA在单变量分析中显示出显著性，但在应用多变量分析时显著性下降。在我们的系列研究中，组织学分级的预后能力似乎主要取决于与核特征相关的子因素。
