Parisi A F, Nieminen M, O'Boyle J E, Moynihan P F, Khuri S F, Kloner R A, Folland E D, Schoen F J
Circulation. 1982 Oct;66(4):764-70. doi: 10.1161/01.cir.66.4.764.
Acute myocardial infarction was produced in 26 dogs by ligation of the left anterior descending coronary artery. Two-dimensional echocardiograms (2-D echoes) were performed through the chest wall before and serially after coronary ligation. The dogs were then killed in four groups at the following intervals: 24-48 hours, 1-2 weeks, 3 weeks and 6-8 weeks. Each 2-D echo was processed through a video quantizer, which encoded echo amplitudes progressively into eight regions of color. The myocardium was graded with respect to color composition in regions that showed any abnormally contracting segment (ACS). The ACS exhibited a progressive increase in echo intensity that became maximal 6-8 weeks after coronary ligation. Histopathologic and histochemical studies verified that these increases in echo amplitude correlated with the evolution of healing and myocardial scar formation. At 6-8 weeks, the mean collagen content of infarcted myocardium had increased by a factor of 4; concurrently, ACS echo amplitude had increased two- to threefold. These observations suggest that color-encoded 2-D echo promotes facile perception of serial changes in tissue characteristics that result from acute myocardial infarction.
通过结扎左冠状动脉前降支，在26只犬身上制造急性心肌梗死。在冠状动脉结扎前及结扎后连续进行经胸壁二维超声心动图（2-D回声）检查。然后将犬分为四组，在以下时间间隔处死：24 - 48小时、1 - 2周、3周和6 - 8周。每个2-D回声通过视频量化器进行处理，该量化器将回声幅度逐步编码为八个颜色区域。对显示任何异常收缩节段（ACS）的区域的心肌进行颜色组成分级。ACS的回声强度逐渐增加，在冠状动脉结扎后6 - 8周达到最大值。组织病理学和组织化学研究证实，这些回声幅度的增加与愈合和心肌瘢痕形成的演变相关。在6 - 8周时，梗死心肌的平均胶原含量增加了4倍；同时，ACS回声幅度增加了两到三倍。这些观察结果表明，颜色编码的2-D回声有助于轻松感知急性心肌梗死导致的组织特征的系列变化。
