Fenster P E, Comess K A, Hanson C D, Finley P R
Clin Pharmacol Ther. 1982 Oct;32(4):428-30. doi: 10.1038/clpt.1982.184.
Digoxin interacts kinetically with many drugs in man. These interactions may result in digoxin toxicity. Aspirin has been shown to raise serum digoxin levels in the dog. We evaluated the effect of aspirin on digoxin single-dose kinetics in eight healthy adults. Aspirin induced no change in digoxin total body clearance, volume of distribution, elimination half-life, or renal or creatinine clearance. Trough serum salicylate levels ranged from 93 to 163 microgram/ml. We conclude that no alteration is required in digoxin dosing when aspirin is used.
地高辛在人体内与许多药物存在动力学相互作用。这些相互作用可能导致地高辛中毒。已证明阿司匹林可使犬血清地高辛水平升高。我们评估了阿司匹林对8名健康成年人地高辛单剂量动力学的影响。阿司匹林对地高辛的全身清除率、分布容积、消除半衰期或肾脏或肌酐清除率均无影响。血清水杨酸谷浓度范围为93至163微克/毫升。我们得出结论，使用阿司匹林时无需改变地高辛的给药剂量。
