Olczyk K, Dróz M, Piwowarczyk P
Exp Pathol. 1982;21(4):221-6. doi: 10.1016/s0232-1513(82)80037-6.
Experimental atherosclerosis in rats was produced by feeding them atherogenic diet for ten months. Elastin and collagen content of the arterial wall as well as some aspects of the metabolism of these proteins were studied. A decrease of elastin content was accompanied by its enhanced susceptibility of enzymatic hydrolysis in vitro. An increase of soluble collagen fractions in tissue and a simultaneously enhanced level of collagen catabolites in serum and urine were found. The present work deals with a disturbed elastin and collagen metabolism in experimental atherosclerosis and shows simultaneous participation of these compounds in pathogenesis of this disease.
通过给大鼠喂食致动脉粥样化饮食十个月来诱导大鼠发生实验性动脉粥样硬化。研究了动脉壁的弹性蛋白和胶原蛋白含量以及这些蛋白质代谢的某些方面。弹性蛋白含量的减少伴随着其在体外对酶促水解敏感性的增强。发现组织中可溶性胶原蛋白组分增加，同时血清和尿液中胶原蛋白分解代谢产物水平升高。本研究探讨了实验性动脉粥样硬化中弹性蛋白和胶原蛋白代谢紊乱的情况，并表明这些化合物同时参与了该疾病的发病机制。
