Kurata M, Hirose K, Umeda M
Gan. 1982 Apr;73(2):217-21.
Effects of organochlorine pesticides on the metabolic cooperation in the hypoxanthine-guanine-phosphoribosyl-transferase system using wild-type 6-thioguanine-sensitive V79 cells and variant 6-thioguanine-resistant cells were surveyed. The metabolic cooperation was inhibited by 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (TDE), 1,1,1-trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (o,p'-DDT), 1,1,1-trichloro-2,2-bis(p-methoxyphenyl)ethane (methoxychlor), aldrin, dieldrin, endrin, heptachlor, alpha-isomer of benzene hexachloride (alpha-BHC), and gamma-BHC, but not beta-BHC. The present results suggest that the pesticides which inhibited the metabolic cooperation may be tumor promoters.
研究了有机氯农药对使用野生型6-硫鸟嘌呤敏感V79细胞和变异型6-硫鸟嘌呤抗性细胞的次黄嘌呤-鸟嘌呤-磷酸核糖转移酶系统中代谢协同作用的影响。代谢协同作用受到1,1,1-三氯-2,2-双（对氯苯基）乙烷（滴滴涕）、1,1-二氯-2,2-双（对氯苯基）乙烷（滴滴伊）、1,1,1-三氯-2-（邻氯苯基）-2-（对氯苯基）乙烷（邻，对'-滴滴涕）、1,1,1-三氯-2,2-双（对甲氧基苯基）乙烷（甲氧滴滴涕）、艾氏剂、狄氏剂、异狄氏剂、七氯、苯六氯的α异构体（α-六六六）和γ-六六六的抑制，但不受β-六六六的抑制。目前的结果表明，抑制代谢协同作用的农药可能是肿瘤促进剂。
