Cox R A, Baker B S, Stevens D A
Infect Immun. 1982 Aug;37(2):609-16. doi: 10.1128/iai.37.2.609-616.1982.
Serum immunoglobulin E (IgE) antibodies were quantitated in 26 patients with active pulmonary coccidioidomycosis, 59 patients with active disseminated disease, 12 patients in clinical remission, and 91 healthy subjects. Significant differences were obtained in IgE serum levels of patients with active disease versus healthy subjects (P less than 0.0001). Patients with pulmonary coccidioidomycosis did not differ in their IgE levels when compared with patients with disseminated disease. However, serum IgE levels were significantly increased in patients with disease involving two or more organ systems when compared with patients with pulmonary disease or extrapulmonary disease involving a single organ system (P less than 0.02). Total serum IgE correlated with anti-Coccidioides IgE (P less than 0.001), but with only six exceptions, patients with anti-Coccidioides IgE also exhibited IgE antibodies to 1 or more of 12 common allergens. The correlation between hyperproduction of IgE and disease severity coupled with the depressed cell-mediated immune status of patients with this disease suggests a defect(s) in the T-lymphocyte population which functions to regulate IgE synthesis.
对26例活动性肺球孢子菌病患者、59例活动性播散性疾病患者、12例临床缓解期患者及91名健康受试者的血清免疫球蛋白E（IgE）抗体进行了定量检测。活动性疾病患者与健康受试者的IgE血清水平存在显著差异（P＜0.0001）。肺球孢子菌病患者与播散性疾病患者的IgE水平无差异。然而，与累及单个器官系统的肺部疾病或肺外疾病患者相比，累及两个或更多器官系统的疾病患者血清IgE水平显著升高（P＜0.02）。血清总IgE与抗球孢子菌IgE相关（P＜0.001），但除6例例外，抗球孢子菌IgE患者还表现出针对12种常见变应原中1种或更多种的IgE抗体。IgE过度产生与疾病严重程度之间的相关性，以及该疾病患者细胞介导免疫状态的降低，提示调节IgE合成的T淋巴细胞群体存在缺陷。
