Tucker L E, Tangedahl T N, Newmark S R
Int J Obes. 1982;6(3):247-51.
Although the association between gallstones and obesity is well known, no attempt has been made to quantitate the increased risk for gallstone formation associated with moderate obesity commonly seen in clinical practice. To determine the prevalence of both asymptomatic and symptomatic gallstones, screening oral cholecystograms were combined with prior documented history in 249 consecutive obese Caucasian women aged 20-59 yr who were seeking treatment for obesity in an out-patient clinic. To ascertain the relative risk of moderate obesity for gallstone formation, the results were compared with a control group of 60 consecutive women who were undergoing screening health examinations in the same clinic. Both groups were without gastrointestinal symptoms. Gallstone prevalence averaged 31 percent among obese women compared to 10 percent in the control group. Sixty percent of gallstones in the combined 20-29 yr age group were asymptomatic. However, among all patients with gallstone disease 59 percent had symptomatic disease evidence by prior cholecystectomy. Moderate obesity imposes at least a three-fold risk of gallstone disease in Caucasian women.
尽管胆结石与肥胖之间的关联已广为人知，但尚未有人尝试对临床实践中常见的中度肥胖与胆结石形成风险增加进行量化。为了确定无症状和有症状胆结石的患病率，对249名年龄在20至59岁、在门诊寻求肥胖治疗的连续白人肥胖女性进行了筛查口服胆囊造影，并结合既往记录的病史。为了确定中度肥胖导致胆结石形成的相对风险，将结果与同一诊所连续接受健康检查的60名女性对照组进行了比较。两组均无胃肠道症状。肥胖女性的胆结石患病率平均为31%，而对照组为10%。在20至29岁的合并年龄组中，60%的胆结石无症状。然而，在所有患有胆结石疾病的患者中，59%的患者通过先前的胆囊切除术有症状性疾病证据。中度肥胖使白人女性患胆结石疾病的风险至少增加三倍。
