Marzio L, Capone F, Neri M, Mezzetti A, De Angelis C, Cuccurullo F
Istituto di Fisiopatologia Medica, Università degli studi di Chieti, Italy.
Dig Dis Sci. 1988 Jan;33(1):4-9. doi: 10.1007/BF01536623.
Gallbladder contractility has been studied in 21 obese patients (greater than 130% ideal weight) and 30 nonobese subjects before and at regular intervals after the administration of a regular solid-liquid meal, and after a low-calorie, low-fat meal used conventionally for weight-loss purposes (Modifast). Gallbladder volume was determined by means of real-time ultrasonography, using a linear array scanner with a 3.5 MHZ probe. In seven of the obese patients, gallbladder contractility was also evaluated after a 10-day regimen with Modifast. The obese group showed a statistically significant greater gallbladder fasting volume and blunted contractility than controls both after the ordinary and the low-calorie meal. The 10-day low-calorie regimen was associated with a statistically significant increment in fasting gallbladder volume, while the percent volume reduction after Modifast did not change. It is suggested that, in addition to metabolic factors, gallbladder hypocontractility in the obese may contribute to the high incidence of cholesterol gallstones noted in these patients. A low-calorie, low-fat diet augmenting gallbladder volume may favor bile stasis and therefore the likelihood of developing gallstones.
在21名肥胖患者（体重超过理想体重的130%）和30名非肥胖受试者中，在给予常规固液混合餐之前、之后定期以及给予传统用于减肥目的的低热量、低脂肪餐（速纤代餐）之后，对胆囊收缩功能进行了研究。使用带有3.5兆赫探头的线性阵列扫描仪，通过实时超声检查来测定胆囊体积。在7名肥胖患者中，在进行10天的速纤代餐方案后，也对胆囊收缩功能进行了评估。肥胖组在普通餐和低热量餐后，胆囊空腹体积在统计学上显著大于对照组，且收缩功能减弱。10天的低热量方案与空腹胆囊体积在统计学上显著增加相关，而速纤代餐之后的体积减少百分比没有变化。有人提出，除代谢因素外，肥胖患者胆囊收缩功能减退可能是这些患者中胆固醇胆结石高发的原因之一。增加胆囊体积的低热量、低脂肪饮食可能有利于胆汁淤积，从而增加形成胆结石的可能性。
