Lee A B, Pitcher-Wilmott R W
Int J Pediatr Otorhinolaryngol. 1982 Aug;4(3):209-14. doi: 10.1016/0165-5876(82)90002-7.
The clinical histories, chest X-ray appearances, skin prick test results, pulmonary function and IgE levels of 20 patients with cystic fibrosis (C.F.) complicated by nasal polyps have been compared with those of 97 C.F. controls. The patients who had developed polyps had a different clustering of symptoms to the controls with heavier birthweights, later presentations, milder gastrointestinal symptoms in infancy, less infection with Staphylococcus aureus and better vital capacities. There was no evidence on history, skin testing or IgE levels that the polyps patients were more allergic. It is likely, therefore, that nasal polyps in C.F. are due to a primary effect of the C.F. gene, although they could also be the effect of chronic nasal infection.
对20例合并鼻息肉的囊性纤维化（C.F.）患者与97例C.F.对照者的临床病史、胸部X线表现、皮肤点刺试验结果、肺功能和IgE水平进行了比较。发生鼻息肉的患者与对照组的症状群不同，其出生体重较重、就诊较晚、婴儿期胃肠道症状较轻、金黄色葡萄球菌感染较少且肺活量较好。从病史、皮肤试验或IgE水平来看，没有证据表明息肉患者更易过敏。因此，C.F.患者的鼻息肉可能是C.F.基因的原发性作用所致，尽管也可能是慢性鼻感染的结果。
