Garay J, Arana J, Alzueta M, Zaldua J, Tovar J
Helv Paediatr Acta. 1982 Jun;37(3):221-30.
Gastroesophageal reflux can be found in patients with respiratory tract disease even in the absence of vomiting. A manometric and pH-metric study carried out in 69 children with radiologic reflux (of whom 49 had respiratory symptoms) and 10 normal controls has shown: 1. lower esophageal sphincter pressure was lower in refluxing patients than in controls, but values were significant only for those with vomiting; 2. all parameters of prolonged esophageal pH-metry indicating reflux were very significantly abnormal in the group of respiratory patients who were by this respect very similar to vomiting refluxers; 3. nevertheless, one fourth to one third of these patients were manometrically and pH-metrically normal. These data confirm that there is a relationship between gastroesophageal reflux and bronchopulmonary disease. A widening of the field of antireflux therapy can be predicted for the near future, although a further definition of the indications is necessary.
即使没有呕吐症状，呼吸道疾病患者也可能出现胃食管反流。对69例有放射学反流表现（其中49例有呼吸道症状）的儿童和10名正常对照者进行的测压和pH值测定研究显示：1. 反流患者的食管下括约肌压力低于对照组，但仅呕吐患者的数值有统计学意义；2. 食管pH值长时间测定显示反流的所有参数在呼吸道疾病组中非常显著异常，在这方面他们与呕吐反流者非常相似；3. 然而，这些患者中有四分之一到三分之一在测压和pH值测定方面正常。这些数据证实胃食管反流与支气管肺疾病之间存在关联。尽管有必要进一步明确适应证，但可以预计在不久的将来抗反流治疗的范围将会扩大。
