Sugano M, Ikeda I, Imaizumi K, Watanabe M, Andoh M
J Nutr Sci Vitaminol (Tokyo). 1982 Apr;28(2):117-26. doi: 10.3177/jnsv.28.117.
Male rats were fed on semipurified cholesterol-free diets containing butter fat with or without supplementary beta-sitosterol. The expected rise of serum cholesterol caused by butter fat, as compared with safflower oil, was not able to be demonstrated, and hence the hypocholesterolemic effect of beta-sitosterol as well. However, the plant sterol effectively lowered the liver cholesterol level. Similar responses were also observed in mice. The distribution of cholesterol in serum lipoproteins remained unchanged among different dietary regimens. Butter fat increased the concentration of serum apoA-I in relation to safflower oil. There was possibly a trend toward higher serum apoA-I with supplementation of beta-sitosterol in a butter-fat diet. The effect of the plant sterol on serum apoB was rather variable. The observation strongly suggests that alteration in cholesterol metabolism in these rodents may not satisfactorily be estimated by the serum cholesterol parameter alone when diets free of cholesterol are fed. The concentration of hepatic cholesterol and serum apolipoproteins seems a more apposite measure for this purpose.
雄性大鼠被喂食含有或不含有补充β-谷甾醇的黄油脂肪的半纯化无胆固醇饮食。与红花油相比，黄油脂肪导致的血清胆固醇预期升高未能得到证实，因此β-谷甾醇的降胆固醇作用也未得到证实。然而，植物甾醇有效地降低了肝脏胆固醇水平。在小鼠中也观察到了类似的反应。不同饮食方案之间，血清脂蛋白中胆固醇的分布保持不变。与红花油相比，黄油脂肪增加了血清载脂蛋白A-I的浓度。在黄油脂肪饮食中补充β-谷甾醇可能有使血清载脂蛋白A-I升高的趋势。植物甾醇对血清载脂蛋白B的影响相当多变。该观察结果强烈表明，当喂食无胆固醇饮食时，仅通过血清胆固醇参数可能无法令人满意地估计这些啮齿动物胆固醇代谢的变化。肝胆固醇和血清载脂蛋白的浓度似乎是用于此目的更合适的指标。
