Kobatake Y, Hirahara F, Innami S, Nishide E
J Nutr Sci Vitaminol (Tokyo). 1983 Feb;29(1):11-21. doi: 10.3177/jnsv.29.11.
The dietary effect of omega-3 type highly polyunsaturated fatty acid concentrate (PUFA mix) was investigated on cholesterol and triglyceride levels in the serum and liver, and high density lipoprotein cholesterol (HDL-cholesterol) levels in the serum. The PUFA mix prepared from squid liver oil contained about 75% of total omega-3 type fatty acids. In rats fed the normal diet to which 3% PUFA mix was added, the levels of triglyceride, total cholesterol and phospholipid in the serum markedly decreased as compared to rats fed a 3% methyl-oleate diet. However, lipid peroxide values in the liver and serum increased in rats fed PUFA mix-diets. In the hypercholesterolemic rats, a 5% PUFA mix-diet caused growth retardation and a corresponding reduction in food intake. Lipid peroxide in the liver and serum were more elevated in rats fed diets containing 1, 3 and 5% PUFA mix than in rats fed diets containing 5% oleate or 5% linoleate. In all the rats on PUFA mix-diets, there were depression of serum total cholesterol and elevation of serum HDL-cholesterol. The ratio of HDL-cholesterol to total cholesterol increased in proportion to the amounts of dietary PUFA mix. Total cholesterol level in the liver was depressed after PUFA mix feeding.
研究了ω-3型高度多不饱和脂肪酸浓缩物（多不饱和脂肪酸混合物）对血清和肝脏中胆固醇及甘油三酯水平以及血清中高密度脂蛋白胆固醇（HDL-胆固醇）水平的饮食影响。由鱿鱼肝油制备的多不饱和脂肪酸混合物含有约75%的总ω-3型脂肪酸。在喂食添加了3%多不饱和脂肪酸混合物的正常饮食的大鼠中，与喂食3%油酸甲酯饮食的大鼠相比，血清中甘油三酯、总胆固醇和磷脂水平显著降低。然而，喂食多不饱和脂肪酸混合物饮食的大鼠肝脏和血清中的脂质过氧化物值升高。在高胆固醇血症大鼠中，5%多不饱和脂肪酸混合物饮食导致生长迟缓以及相应的食物摄入量减少。喂食含1%、3%和5%多不饱和脂肪酸混合物饮食的大鼠肝脏和血清中的脂质过氧化物比喂食含5%油酸或5%亚油酸饮食的大鼠升高得更多。在所有喂食多不饱和脂肪酸混合物饮食的大鼠中，血清总胆固醇降低，血清HDL-胆固醇升高。HDL-胆固醇与总胆固醇的比值与饮食中多不饱和脂肪酸混合物的量成比例增加。喂食多不饱和脂肪酸混合物后，肝脏中的总胆固醇水平降低。
