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人类新生儿红细胞的胰岛素受体特征

Insulin receptor characteristics of erythrocytes from human newborns.

作者信息

Gambhir K K, Nerurkar S G, Allen T, Hill R M, Sekhon H S, Westney L S

出版信息

J Natl Med Assoc. 1982 Apr;74(4):331-7.

Abstract

Erythrocytes from human newborns were observed to have specific insulin receptors. The characteristics of these receptors were similar to those of the normal adult subjects. An observed slight increase in R(o) and a decrease in K̄(e) of insulin receptors in erythrocytes may be speculated to facilitate the transfer of insulin from the fetal erythrocytes to other rapidly growing fetal tissues at a rate faster than that present in the circulation of the adult subjects.

摘要

观察到人类新生儿的红细胞具有特定的胰岛素受体。这些受体的特征与正常成人受试者的相似。红细胞中胰岛素受体的R(o)略有增加和K̄(e)略有降低,这可能有助于胰岛素以比成人受试者循环中更快的速度从胎儿红细胞转移到其他快速生长的胎儿组织。

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本文引用的文献

2
Erythrocyte insulin receptors in chronic renal failure.
Nephron. 1981;28(1):4-10. doi: 10.1159/000182086.
3
Insulin binding to erythrocytes: a negative correlation with red cell age.
J Clin Endocrinol Metab. 1980 Jul;51(1):46-50. doi: 10.1210/jcem-51-1-46.
9
Cooperativity in ligand binding: a new graphic analysis.配体结合中的协同性:一种新的图形分析方法
Biochem Biophys Res Commun. 1975 Oct 27;66(4):1118-26. doi: 10.1016/0006-291x(75)90473-8.

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