Rejent T A, Doyle R E
J Anal Toxicol. 1982 Jul-Aug;6(4):199-201. doi: 10.1093/jat/6.4.199.
A new tetracyclic antidepressant drug, maprotiline hydrochloride was found to be the agent of death in a 23-year-old subject following massive injestion (4.5-6.0 g). The case may be the first reported maprotiline death (sole cause) in the United States. Analytical parameters were studies and various chromatographic and spectrophotometric systems are reported. Quantitation was performed by gas-liquid chromatography using a nitrogen-phosphorous detector. Concentrations of the compound in biological fluids and tissues are also reported.
一种新型四环抗抑郁药盐酸马普替林，在一名23岁患者大量服用（4.5 - 6.0克）后被发现是致死药物。该病例可能是美国首例报告的（唯一死因）马普替林致死案例。研究了分析参数，并报告了各种色谱和分光光度系统。采用氮磷检测器通过气液色谱法进行定量分析。还报告了生物体液和组织中该化合物的浓度。
