Maggi C A, Meli A
J Pharmacol Methods. 1982 Aug;8(1):39-46. doi: 10.1016/0160-5402(82)90006-7.
An in vivo procedure for evaluating potential organ selectivity of spasmolytics has been developed. This involves the determination of comparative potencies, expressed as DR10 of spasmolytics against contractions induced by topical application of acetylcholine on rat colon, rectum and urinary bladder. Experiments with two well known spasmolytics, namely N-butyl-scopolammonium bromide and dicyclomine HCl yielded results consistent with data reported in the literature. This procedure provides a rapid, inexpensive and rather accurate estimate of organ selectivity of spasmolytics.
已开发出一种用于评估解痉药潜在器官选择性的体内实验方法。这涉及测定比较效能，以解痉药对局部应用乙酰胆碱诱导的大鼠结肠、直肠和膀胱收缩的DR10表示。使用两种知名解痉药（即溴化N - 丁基东莨菪碱和盐酸双环胺）进行的实验结果与文献报道的数据一致。该方法能快速、廉价且较为准确地评估解痉药的器官选择性。
