Fukuzawa K, Tokumura A, Ouchi S, Tsukatani H
Lipids. 1982 Jul;17(7):511-3. doi: 10.1007/BF02535334.
The antioxidant activities of 4 tocopherols, tocol, and a water-soluble model analog of alpha-tocopherol were compared. Egg lecithin liposomes were used and oxidation was catalyzed by Fe2+-ascorbate. The activities decreased in the order alpha greater than beta greater than gamma greater than delta-tocopherol greater than tocol, in agreement with their potencies in vivo. The water-soluble analog was the least effective. Activity depended on the molar ratio of antioxidant to unsaturated lipid, with one molecule each of the alpha-, beta-, gamma-, delta-tocopherol and tocol capable of protecting, respectively, 220, 120, 100, 30 and 20 molecules of polyunsaturated fatty acid. The mechanism of possible antioxidant effect of the compounds used is discussed.
比较了4种生育酚、母育酚以及α-生育酚的一种水溶性模型类似物的抗氧化活性。使用了卵磷脂脂质体，并由亚铁离子-抗坏血酸催化氧化反应。活性顺序为α-生育酚＞β-生育酚＞γ-生育酚＞δ-生育酚＞母育酚，这与它们在体内的效能一致。水溶性类似物效果最差。活性取决于抗氧化剂与不饱和脂质的摩尔比，一分子的α-、β-、γ-、δ-生育酚和母育酚分别能够保护220、120、100、30和20个多不饱和脂肪酸分子。讨论了所用化合物可能的抗氧化作用机制。
