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Stereoselective metabolism of the (+)- and (-)-enantiomers of trans-1,2-dihydroxy-1,2-dihydrochrysene to bay-region 1,2-diol-3,4-epoxide diastereomers by rat liver enzymes.

作者信息

Vyas K P, Levin W, Yagi H, Thakker D R, Ryan D E, Thomas P E, Conney A H, Jerina D M

出版信息

Mol Pharmacol. 1982 Jul;22(1):182-9.

PMID:7121449
Abstract
摘要

相似文献

1
Stereoselective metabolism of the (+)- and (-)-enantiomers of trans-1,2-dihydroxy-1,2-dihydrochrysene to bay-region 1,2-diol-3,4-epoxide diastereomers by rat liver enzymes.大鼠肝脏酶将反式-1,2-二羟基-1,2-二氢 Chrysene 的（+）-和（-）-对映体立体选择性代谢为湾区 1,2-二醇-3,4-环氧化物非对映异构体。
Mol Pharmacol. 1982 Jul;22(1):182-9.
2
Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes.大鼠肝脏酶将屈和菲代谢为湾区二醇环氧化物。
Mol Pharmacol. 1981 Jan;19(1):168-78.
3
Metabolism of (-)-trans-(3R, 4R)-dihydroxy-3,4-dihydrochrysene to diol epoxides by liver microsomes.肝脏微粒体将(-)-反式-(3R, 4R)-二羟基-3,4-二氢 Chrysene 代谢为二醇环氧化物。
Biochem Biophys Res Commun. 1981 Feb 27;98(4):961-9. doi: 10.1016/0006-291x(81)91204-3.
4
Stereoselective formations of K-region and non-K-region epoxides in the metabolism of chrysene by rat liver microsomal cytochrome P-450 isozymes.大鼠肝脏微粒体细胞色素P-450同工酶在屈代谢过程中K区域和非K区域环氧化物的立体选择性形成。
Mol Pharmacol. 1987 Jul;32(1):73-80.
5
Regioselectivity and stereoselectivity in the metabolism of trans-1,2-dihydroxy-1,2-dihydrobenz[a]anthracene by rat liver microsomes.大鼠肝微粒体对反式-1,2-二羟基-1,2-二氢苯并[a]蒽代谢的区域选择性和立体选择性
Mol Pharmacol. 1983 Jul;24(1):115-23.
6
Novel stereoselectivity of rat liver cytochrome(s) P450 toward enantiomers of the trans-1,2-dihydrodiol of triphenylene.大鼠肝脏细胞色素P450对三亚苯反式-1,2-二氢二醇对映体的新型立体选择性。
Arch Biochem Biophys. 1991 Jul;288(1):54-63. doi: 10.1016/0003-9861(91)90164-e.
7
Stereoselective metabolism of the (+)-(S,S)- and (-)-(R,R)-enantiomers of trans-3,4-dihydroxy-3,4-dihydrobenzo[c]-phenanthrene by rat and mouse liver microsomes and by a purified and reconstituted cytochrome P-450 system.大鼠和小鼠肝脏微粒体以及纯化和重组的细胞色素P-450系统对反式-3,4-二羟基-3,4-二氢苯并[c]菲的(+)-(S,S)-和(-)-(R,R)-对映体的立体选择性代谢。
J Biol Chem. 1986 Apr 25;261(12):5404-13.
8
Regioselective and stereoselective metabolisms of pyrene and 1-bromopyrene by rat liver microsomes and effects of enzyme inducers.
Drug Metab Dispos. 1988 Mar-Apr;16(2):173-83.
9
Stereoselective metabolism of dibenz[a,h]acridine to bay-region diol epoxides by rat liver microsomes.大鼠肝微粒体对二苯并[a,h]吖啶的立体选择性代谢生成湾区二醇环氧化物
Carcinogenesis. 1995 Mar;16(3):525-30. doi: 10.1093/carcin/16.3.525.
10
The effect of enzyme induction on the stereoselective metabolism of optically pure (-)1R,2R- and (+)1S,2S-dihydroxy-1,2-dihydrobenz-[a]anthracenes to vicinal 1,2-dihydrodiol 3,4-epoxides by rat liver microsomes.酶诱导对大鼠肝微粒体将光学纯的(-)1R,2R-和(+)1S,2S-二羟基-1,2-二氢苯并[a]蒽立体选择性代谢为邻位1,2-二氢二醇3,4-环氧化物的影响。
Carcinogenesis. 1983;4(5):629-38. doi: 10.1093/carcin/4.5.629.

引用本文的文献

1
Mutagenicity and tumorigenicity of the four enantiopure bay-region 3,4-diol-1,2-epoxide isomers of dibenz[a,h]anthracene.并苯[a,h]蒽四个对映体 3,4-二羟基-1,2-环氧化物的致突变性和致癌性。
Carcinogenesis. 2013 Sep;34(9):2184-91. doi: 10.1093/carcin/bgt164. Epub 2013 May 13.
2
Urinary and faecal excretion of chrysene and chrysene metabolites by rats after oral, intraperitoneal, intratracheal or intrapulmonary application.
Arch Toxicol. 1988;62(6):401-5. doi: 10.1007/BF00288341.