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Urinary and faecal excretion of chrysene and chrysene metabolites by rats after oral, intraperitoneal, intratracheal or intrapulmonary application.

作者信息

Grimmer G, Brune H, Dettbarn G, Heinrich U, Jacob J, Mohtashamipur E, Norpoth K, Pott F, Wenzel-Hartung R

机构信息

Biochemical Institute for Environmental Carcinogens, Grosshansdorf, Federal Republic of Germany.

出版信息

Arch Toxicol. 1988;62(6):401-5. doi: 10.1007/BF00288341.

DOI:10.1007/BF00288341
PMID:3250370
Abstract

The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas chromatography/mass spectrometry. The metabolite profile was found to depend on the mode of excretion and on the route of administration. In all cases the oxidation of chrysene in the 1,2- or 3,4-position predominates, whereas oxidation in the 5,6-position (K-region) seems be a minor pathway.

摘要

相似文献

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Urinary and faecal excretion of chrysene and chrysene metabolites by rats after oral, intraperitoneal, intratracheal or intrapulmonary application.
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本文引用的文献

1
The metabolism of chrysene: the isolation of 3-methoxychrysene by methylation of the phenolic metabolite of chrysene from rat faeces.屈的代谢：通过对大鼠粪便中屈的酚类代谢物进行甲基化反应分离得到3-甲氧基屈。
Biochem J. 1949;44(5):604-6. doi: 10.1042/bj0440604.
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The intermediary metabolism of polycyclic hydrocarbons.多环烃的中间代谢
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METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 9,10-EPOXY-9,10-DIHYDROPHENANTHRENE IN RATS.多环化合物的代谢。大鼠体内9,10 - 环氧 - 9,10 - 二氢菲的代谢
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Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes.大鼠肝脏酶将屈和菲代谢为湾区二醇环氧化物。
Mol Pharmacol. 1981 Jan;19(1):168-78.
5
The metabolic activation of chrysene by hamster embryo cells.仓鼠胚胎细胞对 Chrysene 的代谢激活作用。
Carcinogenesis. 1982;3(9):1051-6. doi: 10.1093/carcin/3.9.1051.
6
Stereoselective metabolism of the (+)- and (-)-enantiomers of trans-1,2-dihydroxy-1,2-dihydrochrysene to bay-region 1,2-diol-3,4-epoxide diastereomers by rat liver enzymes.大鼠肝脏酶将反式-1,2-二羟基-1,2-二氢 Chrysene 的（+）-和（-）-对映体立体选择性代谢为湾区 1,2-二醇-3,4-环氧化物非对映异构体。
Mol Pharmacol. 1982 Jul;22(1):182-9.
7
Metabolic conversion of dibenz[a,h]anthracene (+/-)trans-1,2-dihydrodiol and chrysene (+/-)trans-3,4-dihydrodiol to vicinal dihydrodiol epoxides.二苯并[a,h]蒽（±）反式-1,2-二氢二醇和屈（±）反式-3,4-二氢二醇向邻位二氢二醇环氧化物的代谢转化。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4270-3. doi: 10.1073/pnas.78.7.4270.
8
The metabolism of a series of polycyclic hydrocarbons by mouse skin maintained in short-term organ culture.
Chem Biol Interact. 1980 Feb;29(2):169-88. doi: 10.1016/0009-2797(80)90031-9.
9
Metabolic activation of chrysene in mouse skin: evidence for the involvement of a triol-epoxide.小鼠皮肤中屈的代谢活化：三醇环氧化物参与的证据。
Carcinogenesis. 1983 Dec;4(12):1639-43. doi: 10.1093/carcin/4.12.1639.
10
Polynuclear aromatic compounds, Part 1, Chemical, environmental and experimental data.多核芳香化合物，第1部分，化学、环境和实验数据。
IARC Monogr Eval Carcinog Risk Chem Hum. 1983 Dec;32:1-453.