Otmakhov N A
Neirofiziologiia. 1982;14(4):410-7.
Responses of the CA3 neurons to mossy fibre stimulation were investigated in incubated hippocampal slices in vitro under the influence of norepinephrine (NE) and 5-hydroxytryptamine (5HT). Both agents modulated the level of background activity (increased or decreased it), changed its pattern and influenced the responses to stimulation of nonaminergic input, facilitating or suppressing it. The changes in response level and pattern usually correlate with the corresponding changes of background activity. In some cases NE, lowering the frequency of background activity but increasing the proportion of "complex discharges" in it as well as the number of reduced spikes with in a complex discharge, increased the responses to stimulation. 5HT which evoked in some cells a periodic grouped activity, facilitated the occurrence of identical groups in response to stimulation. Unlike NF which evoked relatively short-term changes, 5HT produced prolonged (up to 40 min) augmentation of background activity and facilitation of responses.
在去甲肾上腺素（NE）和5-羟色胺（5HT）影响下，对体外培养的海马切片中CA3神经元对苔藓纤维刺激的反应进行了研究。这两种物质都调节背景活动水平（增加或降低），改变其模式，并影响对非胺能输入刺激的反应，促进或抑制这种反应。反应水平和模式的变化通常与背景活动的相应变化相关。在某些情况下，NE降低背景活动频率，但增加其中“复合放电”的比例以及复合放电中减少的尖峰数量，增加对刺激的反应。5HT在某些细胞中引起周期性成组活动，促进刺激时相同组的出现。与引起相对短期变化的NE不同，5HT使背景活动延长增强（长达40分钟）并促进反应。
