Otmakhov N A, Bragin A G
Neirofiziologiia. 1981;13(5):482-90.
Effect of norepinephrine (NE) and 5-hydroxytryptamine (5-HT) upon the background activity of neurons in hippocampal slices (field CA3) was investigated during injection transmitter substances to the incubation medium. Both NE and 5-HT may suppress (32 and 49%, respectively) or activate (52 and 35%) the background activity. Activation was observed mainly in the cells without background discharges or with single spike irregular activity. Suppression of activity was observed in the units with "complex spikes". Activatory effects of NE, but not of 5-HT, could be imitated by NE against phenylephrine and blocked by alpha-adrenoreceptor blocker phentolamine. Effects of transmitter substances were maintained in the medium with increased Mg2+ concentration.
在向孵育培养基中注射递质物质期间，研究了去甲肾上腺素（NE）和5-羟色胺（5-HT）对海马切片（CA3区）神经元背景活动的影响。NE和5-HT均可抑制（分别为32%和49%）或激活（分别为52%和35%）背景活动。激活主要在无背景放电或有单个棘波不规则活动的细胞中观察到。在有“复合棘波”的单位中观察到活动抑制。NE的激活作用（而非5-HT的激活作用）可被NE对抗去氧肾上腺素所模拟，并被α-肾上腺素能受体阻滞剂酚妥拉明阻断。递质物质的作用在Mg2+浓度升高的培养基中得以维持。
