Craggs M D, Stephenson J D
Neuropharmacology. 1982 Jul;21(7):695-703. doi: 10.1016/0028-3908(82)90013-2.
Voiding induced in conscious cats by infusion of sterile saline into the bladder via a chronically implanted bladder catheter was stable over many months. Artefact-free recordings of electrical activity obtained from the bladder neck and dome of these preparations during bladder filling and voiding showed characteristic voiding electromyograms but did not permit a functional differentiation. Both voiding and the associated electromyogram were abolished by the ganglion blocking agent, pentolinium. Hyoscine or methyl atropine did not affect the electromyogram but impaired the ability of cats to empty their bladders completely. In anaesthetized cats, ganglion blocking agents prevented a rise in bladder pressure during sacral ventral root stimulation but a hyoscine-sensitive bladder contraction was seen following the period of stimulation. Further stimulation during this post-stimulus rise in intravesical pressure revealed a hyoscine-sensitive stimulus-bound relaxation. Sacral ventral root stimulation relaxed the bladder neck/proximal urethra particularly in the presence of sympathetic tone.
通过经长期植入的膀胱导管向膀胱内注入无菌生理盐水，在清醒猫身上诱发的排尿在数月内保持稳定。在这些实验准备中，在膀胱充盈和排尿期间从膀胱颈和膀胱顶部获得的无伪迹电活动记录显示出特征性的排尿肌电图，但无法进行功能区分。排尿和相关的肌电图均被神经节阻断剂潘托铵消除。东莨菪碱或甲基阿托品不影响肌电图，但损害了猫完全排空膀胱的能力。在麻醉猫中，神经节阻断剂可防止骶前根刺激期间膀胱压力升高，但在刺激期后可观察到对东莨菪碱敏感的膀胱收缩。在刺激后膀胱内压升高期间的进一步刺激显示出对东莨菪碱敏感的刺激相关松弛。骶前根刺激可使膀胱颈/近端尿道松弛，尤其是在存在交感神经张力的情况下。
