Bickford P C, Palmer M R, Hoffer B J, Freedman R
Neuropharmacology. 1982 Aug;21(8):729-32. doi: 10.1016/0028-3908(82)90056-9.
The interaction between phencyclidine and acetylcholine-evoked responses of hippocampal pyramidal neurons was investigated in normal and catecholamine-depleted rats. Phencyclidine antagonized the acetylcholine-induced excitations in both preparations. However, in the majority of cases, this effect was observed only at doses of phencyclidine which also manifested nonspecific membrane stabilization. In contrast, phencyclidine-induced decreases in firing rate, which have been shown to be mediated by catecholamines, occurred at doses of phencyclidine which do not cause local anesthesia. Taken together, these data suggest that the catecholaminergically-mediated effects of phencyclidine may be more important in the hippocampus.
在正常大鼠和去甲肾上腺素耗竭的大鼠中，研究了苯环己哌啶与海马锥体神经元乙酰胆碱诱发反应之间的相互作用。苯环己哌啶拮抗了两种制剂中乙酰胆碱诱导的兴奋作用。然而，在大多数情况下，仅在也表现出非特异性膜稳定作用的苯环己哌啶剂量下才观察到这种效应。相比之下，已证明由儿茶酚胺介导的苯环己哌啶引起的放电率降低，发生在不会引起局部麻醉的苯环己哌啶剂量下。综上所述，这些数据表明苯环己哌啶的儿茶酚胺能介导效应在海马体中可能更重要。
