Chan R C, Steinbok P
Neurosurgery. 1982 Aug;11(2):254-7. doi: 10.1227/00006123-198208000-00009.
The authors report 57 patients in whom craniotomies for solitary intracranial metastatic tumor were performed in Vancouver General Hospital between 1970 and 1980. The median survival after craniotomy varied between 3.5 and 10 months depending upon the types of primary tumors. Patients with metastatic central nervous system (CNS) tumor from breast, kidney, or an unknown primary site had longer periods of survival than those with bronchogenic carcinoma. The outcome for metastatic melanoma was poor. Eighty-two per cent of the patients were able to enjoy home life and were self-dependent at the time of discharge from the hospital. A long latent interval between the primary tumor diagnosis and secondary CNS metastasis favored longer survival for patients with bronchogenic carcinoma, but not for those with melanoma. The presence of systemic metastases was an adverse factor. There was no significant difference in the duration of survival between patients with right- or left-sided cerebral lesions, but those with right hemispheric involvement had a better quality of survival. The use of computed tomographic scanning improved both the duration and the quality of postoperative survival.
作者报告了1970年至1980年间在温哥华总医院接受开颅手术治疗孤立性颅内转移瘤的57例患者。开颅术后的中位生存期在3.5至10个月之间，具体取决于原发肿瘤的类型。来自乳腺、肾脏或原发部位不明的转移性中枢神经系统（CNS）肿瘤患者的生存期比支气管源性癌患者更长。转移性黑色素瘤的预后较差。82%的患者在出院时能够享受家庭生活并自理。原发肿瘤诊断与继发性CNS转移之间的长潜伏期有利于支气管源性癌患者的生存期延长，但对黑色素瘤患者则不然。存在全身转移是一个不利因素。右侧或左侧脑病变患者的生存期没有显著差异，但右侧半球受累的患者生存质量更好。计算机断层扫描的应用改善了术后生存期和生存质量。
