Salvati M, Cervoni L, Delfini R
Mediterranean Sanatrix Institute of Neurosciences, IRCCS, Pozzilli (Is) Italy.
Neurosurg Rev. 1996;19(4):221-5. doi: 10.1007/BF00314834.
The authors report 91 cases of solitary brain metastasis from non-oat cell lung cancer, 66 patients were males and 25 females; average age was 57 years (range 40-72 years). Surgical removal was total in 80 cases and partial in 11. All patients received postoperative radiotherapy and 40 chemotherapy. Histologically, the tumor was an adenocarcinoma in 51 cases (56%), a squamous cell carcinoma in 22 (24%), an undifferentiated carcinoma in 18 (20%). Median survival was 16 months and the main cause of death was progression of the primary cancer (59% of cases). Survival was influenced by staging of the primary tumor, while no prognostic significance was found regarding the type of clinical tumor onset, type of radiotherapy and the histotype of the lesion. Use of the "no internal touch" technique and brain radiotherapy reduced local brain relapse.
作者报告了91例非小细胞肺癌的孤立性脑转移病例，其中男性66例，女性25例；平均年龄57岁（范围40 - 72岁）。80例行肿瘤全切术，11例行部分切除术。所有患者术后均接受放疗，40例接受化疗。组织学检查显示，肿瘤为腺癌51例（56%），鳞状细胞癌22例（24%），未分化癌18例（20%）。中位生存期为16个月，主要死亡原因是原发癌进展（59%的病例）。生存期受原发肿瘤分期影响，而临床肿瘤起病类型、放疗类型及病变组织类型无预后意义。“无瘤操作”技术及脑部放疗可减少局部脑复发。
