Colina F, Solis-Herruzo J A, Munoz-Yagüe M T, Vazquez G, Perez-Barrios A
Postgrad Med J. 1982 Jun;58(680):390-5. doi: 10.1136/pgmj.58.680.390.
A woman aged 23 years is described who had watery diarrhoea and colicky abdominal pain with normal results on sigmoidoscopy and barium enema. Rectal biopsy showed a thick layer of collagen in the lamina propria below the free epithelial surface. This lesion extended throughout the length of the descending colon. The only change revealed by electron microscopy was an increase in the thickness of the sub-epithelial collagen layer which is normally present in the colon. The maturation of the fibroblasts was normal. The lesion in this patient may be considered as a small change from the normal situation. This lesion is typical of ‘collagenous colitis’ of which only three other cases have as yet been published.
本文描述了一位23岁女性，她患有水样腹泻和绞痛性腹痛，乙状结肠镜检查和钡灌肠结果正常。直肠活检显示，在游离上皮表面下方的固有层中有一层厚厚的胶原蛋白。该病变延伸至降结肠全长。电子显微镜检查显示的唯一变化是结肠中正常存在的上皮下胶原层厚度增加。成纤维细胞成熟正常。该患者的病变可被视为与正常情况的微小差异。这种病变是“胶原性结肠炎”的典型表现，迄今为止仅另有三例相关病例发表。
