Leach C M, Thorburn G D
Prostaglandins. 1982 Jul;24(1):47-59. doi: 10.1016/0090-6980(82)90176-9.
The role of thromboxane in human, rabbit, dog, pig and sheep platelet aggregation has been studied. Each of these species showed a concentration-dependent relationship between collagen concentrations and the thromboxane B2 (TXB2) released from aggregating platelets, however sheep platelets produced only 17.5% of the amount of TXB2 released from human platelets under the same collagen stimulus. Indomethacin did not inhibit sheep platelet aggregation in the concentration range 0.114 mM - 0.114 muM, yet proved to be a potent inhibitor of human platelet aggregation. The prostaglandin endoperoxide analogue, U.46619, induced human platelet aggregation at a dose of 100 ng, however the analogue, at doses as high as 500 micrograms was much less active on sheep platelets when compared to human platelets. Thus we have demonstrated that there are differences in the extent of thromboxane involvement in platelet aggregation between different species, which must be considered with other criteria, before choosing an animal model for studying human atherosclerosis.
已经对血栓素在人、兔、狗、猪和羊血小板聚集中的作用进行了研究。这些物种中的每一种在胶原浓度与聚集血小板释放的血栓素B2（TXB2）之间均呈现浓度依赖性关系，然而在相同的胶原刺激下，羊血小板产生的TXB2量仅为人血小板释放量的17.5%。吲哚美辛在0.114 mM至0.114 μM的浓度范围内不抑制羊血小板聚集，但被证明是人类血小板聚集的有效抑制剂。前列腺素内过氧化物类似物U.46619在剂量为100 ng时可诱导人血小板聚集，然而与人类血小板相比，该类似物在高达500微克的剂量下对羊血小板的活性要低得多。因此，我们已经证明，不同物种之间血栓素参与血小板聚集的程度存在差异，在选择用于研究人类动脉粥样硬化的动物模型之前，必须结合其他标准来考虑这一点。
