Inhibitory effect of vitamin E on lipoperoxide formation in rat adrenal gland.

The tissue uptake of vitamin E administered to the rats was strikingly high in the adrenal glands, and microradioautographic studies showed that the vitamin was localized morphologically in the cells of fascicular and reticular zones of the adrenal cortex, where lipofuscin pigment appears with aging. On the other hand, it was confirmed that the TBA content in rat plasma and adrenal gland was elevated following whole-body 60Co irradiation as an aging model. It was also demonstrated that the TBA content in rat adrenal markedly increased in conditions of vitamin E deficiency with and without irradiation.