Noble R C, Shand J H, Drummond J T, Moore J H
J Nutr. 1978 Nov;108(11):1868-76. doi: 10.1093/jn/108.11.1868.
A polyunsaturated fatty acid supplement, protected from biohydrogenation in the rumen by a formaldehyde-treated protein coat, was fed to ewes during the last 8 weeks of pregnancy as a possible method of improving the poor essential fatty acid status of the newborn lambs. Significant increases were observed in the concentrations of 18:2 (n-6) in both the cholesteryl ester and phospholipid fractions of the plasma and in the phospholipid fraction of the liver of the lamb at birth. Concomitantly, there were significant increases in 20:4 (n-6) concentrations and reductions in the concentrations of 20:3 (n-9). In addition, the concentration of 18:2 (n-6) in the colostrum of the ewes was increased some eightfold thereby providing a secondary source of this essential fatty acid to the lamb. A marked decrease in erythrocyte fragility was observed in lambs whose ewes had received the "protected" polyunsaturated fatty acid diet. These findings are discussed in relation to the known metabolic roles of essential fatty acids in the animal body, with particular reference to the essential fatty acid status of the lamb at birth.
在母羊怀孕的最后8周，给它们喂食一种用甲醛处理过的蛋白包衣保护的多不饱和脂肪酸补充剂，以此作为改善新生羔羊必需脂肪酸状况不佳的一种可能方法。在出生时，羔羊血浆中胆固醇酯和磷脂部分以及肝脏磷脂部分的18:2（n-6）浓度显著增加。同时，20:4（n-6）浓度显著增加，20:3（n-9）浓度降低。此外，母羊初乳中18:2（n-6）的浓度增加了约八倍，从而为羔羊提供了这种必需脂肪酸的次要来源。在母羊接受“保护型”多不饱和脂肪酸饮食的羔羊中，观察到红细胞脆性显著降低。结合必需脂肪酸在动物体内已知的代谢作用，特别是新生羔羊的必需脂肪酸状况，对这些发现进行了讨论。
