Shand J H, Noble R C, Moore J H
Biol Neonate. 1978;34(5-6):217-24. doi: 10.1159/000241132.
A "protected" polyunsaturated fatty acid supplement was fed to ewes during the last 8 weeks of pregnancy. The effect of this dietary supplement on the essential fatty acid composition of the liver phospholipids and associated changes in the liver delta9- and delta6-desaturase activities were investigated and compared with the effects of directly dosing the newborn lambs for 8 days with an unprotected polyunsaturated oil, maize oil. The maternal dietary supplement produced significant changes in the essential fatty acid composition of the neonatal lamb liver phospholipids. Although the liver delta6-desaturase activity in these animals was also significantly higher than in the lambs from control ewes, the delta9-desaturase was unaffected by maternal dietary supplementation. Direct dosing of the newborn lambs with maize oil failed to produce any signficant changes either in the liver phospholipid fatty acid composition or in the delta9- and delta6-desaturase activities. These results are discussed in terms of the dietary control of liver desaturase enzyme systems.
在怀孕的最后8周，给母羊喂食一种“受保护的”多不饱和脂肪酸补充剂。研究了这种膳食补充剂对肝脏磷脂中必需脂肪酸组成的影响以及肝脏Δ9-和Δ6-去饱和酶活性的相关变化，并与直接给新生羔羊喂食未受保护的多不饱和油（玉米油）8天的效果进行了比较。母体膳食补充剂使新生羔羊肝脏磷脂的必需脂肪酸组成发生了显著变化。尽管这些动物肝脏中的Δ6-去饱和酶活性也显著高于对照母羊所产羔羊，但Δ9-去饱和酶不受母体膳食补充的影响。直接给新生羔羊喂食玉米油，无论是肝脏磷脂脂肪酸组成还是Δ9-和Δ6-去饱和酶活性，均未产生任何显著变化。根据肝脏去饱和酶系统的膳食控制对这些结果进行了讨论。
