McBride M C, Kemper T L
Acta Neuropathol. 1982;57(2-3):93-8. doi: 10.1007/BF00685375.
Microgyria (polygria, polymicrogyria) has stimulated continued interest since its first description by Meschede [28]. Based on analysis of case material, available staining techniques, and known principles of human cortical development, subsequent investigators have proposed numerous theories to explain its pathogenesis. We have studied a case which cannot be fully explained by these previously proposed theories. In this case, four-layered microgyria is present bilaterally in middle cerebral artery distribution, but in one hemisphere, in the center of the malformed area, the deep acellular and cellular layers are replaced by radially aligned neurons extending ectopically into prospective white matter. Analysis of the findings in this case provide evidence that the recently described pathogenetic mechanism observed in a rat model of this malformation [15,16] is applicable to its formation in man.
自梅谢德首次描述微小脑回（多小脑回、多微小脑回）以来，它一直引发着持续的关注[28]。基于对病例资料、现有染色技术以及人类皮质发育已知原理的分析，后续研究人员提出了众多理论来解释其发病机制。我们研究了一个用先前提出的理论无法完全解释的病例。在该病例中，双侧大脑中动脉分布区存在四层微小脑回，但在一个半球的畸形区域中心，深层无细胞层和细胞层被异位延伸至预期白质的放射状排列神经元所取代。对该病例研究结果的分析提供了证据，表明在这种畸形的大鼠模型中最近描述的发病机制[15,16]适用于其在人类中的形成。
